Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305.
Cold Spring Harb Perspect Med. 2013 Dec 1;3(12):a010348. doi: 10.1101/cshperspect.a010348.
Some host-adapted bacterial pathogens are capable of causing persistent infections in humans. For example, Helicobacter pylori inhabits the human gastric mucosa and persistence can be lifelong. Salmonella enterica serovar Typhi causes systemic infections that involve colonization of the reticuloendothelial system and some individuals become lifelong carriers. In this review, I compare and contrast the different lifestyles of Helicobacter and Salmonella within the host and the strategies they have evolved to persist in mammalian hosts. Persistently infected carriers serve as the reservoirs for these pathogens, and the carrier state is an essential feature that is required for survival of the bacteria within a restricted host population. Therefore, investigating the chronic carrier state should provide insight into bacterial survival strategies, as well as new therapeutic approaches for treatments.
一些宿主适应的细菌病原体能够在人类中引起持续性感染。例如，幽门螺杆菌栖息在人类胃黏膜中，可以终生存在。伤寒沙门氏菌血清型引起全身性感染，涉及网状内皮系统的定植，一些个体成为终生携带者。在这篇综述中，我比较和对比了幽门螺杆菌和沙门氏菌在宿主中的不同生活方式，以及它们在哺乳动物宿主中持续存在所进化出的策略。持续性感染的携带者是这些病原体的储存库，而携带状态是细菌在有限宿主群体中生存所必需的特征。因此，研究慢性携带状态应该为细菌的生存策略以及治疗的新治疗方法提供深入的了解。
