Meis J M, Ordóñez N G, Bruner J M
Arch Pathol Lab Med. 1986 Oct;110(10):934-7.
Fifty formalin-fixed, paraffin-embedded meningiomas were studied with a panel of ten antibodies directed against epithelial antigens, intermediate filaments, and neuroectodermal antigens. Twenty-five (50%) of these were stained with monoclonal antibodies (MoAb) to epithelial membrane antigen (EMA), 12 (24%) with keratin antibodies, 9 (18%) for vimentin, and 4 (8%) for S100 protein. Monoclonal antibodies to Leu-7, desmin, neurofilament 200 kDa, and glial fibrillary acidic protein (GFAP) all failed to stain any of the 50 neoplasms. Overall, 34 (68%) meningiomas stained with one or more antibodies. Sixteen (32%) failed to stain at all. The dual epithelial and mesenchymal nature of meningiomas is supported in this study. Applications to diagnostic surgical pathology and histogenetic implications are discussed.
采用一组针对上皮抗原、中间丝和神经外胚层抗原的十种抗体，对50例福尔马林固定、石蜡包埋的脑膜瘤进行了研究。其中25例（50%）用抗上皮膜抗原（EMA）的单克隆抗体（MoAb）染色，12例（24%）用角蛋白抗体染色，9例（18%）用波形蛋白染色，4例（8%）用S100蛋白染色。抗Leu-7、结蛋白、200 kDa神经丝和胶质纤维酸性蛋白（GFAP）的单克隆抗体均未能对50例肿瘤中的任何一例进行染色。总体而言，34例（68%）脑膜瘤用一种或多种抗体染色。16例（32%）完全未染色。本研究支持脑膜瘤的双重上皮和间充质性质。讨论了其在诊断性外科病理学中的应用及组织发生学意义。
