一种消除钙依赖性钾电流的果蝇突变。
A Drosophila mutation that eliminates a calcium-dependent potassium current.
作者信息
Elkins T, Ganetzky B, Wu C F
出版信息
Proc Natl Acad Sci U S A. 1986 Nov;83(21):8415-9. doi: 10.1073/pnas.83.21.8415.
Abstract
A mutation of Drosophila, slowpoke (slo), specifically abolishes a Ca2+-dependent K+ current, IC, from dorsal longitudinal flight muscles of adult flies. Other K+ currents remain normal, providing evidence that IC is mediated by a molecularly distinguishable set of channels. The pharmacological properties of IC are similar to those of Ca2+-dependent currents in some vertebrate cells. The muscle action potential was significantly lengthened in slo flies, indicating that IC plays the major role in its repolarization.
摘要
果蝇的一种突变体——慢poke（slo），特异性地消除了成年果蝇背纵飞行肌中的一种钙依赖性钾电流IC。其他钾电流保持正常，这证明IC是由一组分子上可区分的通道介导的。IC的药理学特性与某些脊椎动物细胞中的钙依赖性电流相似。slo果蝇的肌肉动作电位显著延长，表明IC在其复极化过程中起主要作用。
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