Barbaglia Yanina, Jiménez Félix, Tedeschi Fabián, Zalazar Fabián
Servicio de Gastroenterología, Hospital Dr J M Cullen, Santa Fe, Argentina.
Acta Gastroenterol Latinoam. 2013 Sep;43(3):231-4.
sophageal squamous papilloma is an uncommon, usually asymptomatic, benign tumor of the squamous epithelium consisting of a raised, sessile, small and round (smooth or rough) lesion. The prevalence is between 0.01 and 0.45% of cases, with a male/female ratio of 3:1. The etiology and pathogenesis appear to be a mechanical or chemical irritation of the mucosa in addition to the presence of human papillomavirus (HPV), important agent in the evolution to a squamous carcinoma, especially HPV types 16 and 18. In this paper, we describe a case of esophageal papilloma whose diagnosis involved endoscopic images, pathological studies and detection of viral DNA by polymerase chain reaction. By using molecular techniques (PCR-RFLP) a profile consistent with HPV type 16 has been obtained. The patient underwent polypectomy and currently, after 3 years of diagnosis, he remains asymptomatic. This work is one of the first national reports of a patient with esophageal papilloma in which one of the most frequently HPV genotypes associated with esophageal carcinoma (HPV 16) has been detected.
食管鳞状乳头状瘤是一种罕见的、通常无症状的鳞状上皮良性肿瘤，由凸起的、无蒂的、小而圆（光滑或粗糙）的病变组成。其患病率在病例的0.01%至0.45%之间，男女比例为3:1。病因和发病机制似乎除了人乳头瘤病毒（HPV）外，还包括黏膜的机械性或化学性刺激，HPV是鳞状细胞癌演变中的重要因素，尤其是16型和18型HPV。在本文中，我们描述了一例食管乳头状瘤病例，其诊断涉及内镜图像、病理研究以及通过聚合酶链反应检测病毒DNA。通过使用分子技术（PCR-RFLP）获得了与16型HPV一致的图谱。患者接受了息肉切除术，目前，在诊断3年后，他仍无症状。这项工作是国内首批关于食管乳头状瘤患者的报告之一，其中检测到了与食管癌相关的最常见HPV基因型之一（HPV 16）。
