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细胞信息库:一个细胞数据资源库。

CellFinder: a cell data repository.

机构信息

Berlin Brandenburg Center for Regenerative Medicine, Charité - Universitätsmedizin Berlin, Berlin 13353, Germany, Max Delbrück Center for Molecular Medicine, Computational Biology and Data Mining, Berlin 13125, Germany, Humboldt Universität zu Berlin, Institute for Computer Science, Berlin 10099, Germany and Seoul National University, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul 151-742, Republic of Korea.

出版信息

Nucleic Acids Res. 2014 Jan;42(Database issue):D950-8. doi: 10.1093/nar/gkt1264. Epub 2013 Dec 3.

Abstract

CellFinder (http://www.cellfinder.org) is a comprehensive one-stop resource for molecular data characterizing mammalian cells in different tissues and in different development stages. It is built from carefully selected data sets stemming from other curated databases and the biomedical literature. To date, CellFinder describes 3394 cell types and 50 951 cell lines. The database currently contains 3055 microscopic and anatomical images, 205 whole-genome expression profiles of 194 cell/tissue types from RNA-seq and microarrays and 553 905 protein expressions for 535 cells/tissues. Text mining of a corpus of >2000 publications followed by manual curation confirmed expression information on ∼900 proteins and genes. CellFinder's data model is capable to seamlessly represent entities from single cells to the organ level, to incorporate mappings between homologous entities in different species and to describe processes of cell development and differentiation. Its ontological backbone currently consists of 204 741 ontology terms incorporated from 10 different ontologies unified under the novel CELDA ontology. CellFinder's web portal allows searching, browsing and comparing the stored data, interactive construction of developmental trees and navigating the partonomic hierarchy of cells and tissues through a unique body browser designed for life scientists and clinicians.

摘要

CellFinder(http://www.cellfinder.org)是一个综合性的一站式资源,用于描述不同组织和不同发育阶段的哺乳动物细胞的分子数据。它是由精心挑选的数据集合构建而成,这些数据来源于其他经过精心整理的数据库和生物医学文献。截至目前,CellFinder 描述了 3394 种细胞类型和 50951 种细胞系。该数据库目前包含 3055 张显微镜和解剖图像、194 种细胞/组织类型的 205 个全基因组表达谱(来自 RNA-seq 和微阵列)以及 535 种细胞/组织的 553905 种蛋白质表达谱。对超过 2000 篇文献的语料库进行文本挖掘,然后进行人工整理,确认了约 900 种蛋白质和基因的表达信息。CellFinder 的数据模型能够无缝地表示从单个细胞到器官水平的实体,纳入不同物种同源实体之间的映射,并描述细胞发育和分化的过程。它的本体骨干目前由 204741 个本体术语组成,这些术语是从 10 个不同的本体中整合而来的,这些本体统一在一个新的 CELDA 本体下。CellFinder 的网络门户允许搜索、浏览和比较存储的数据,交互式构建发育树,并通过专为生命科学家和临床医生设计的独特身体浏览器导航细胞和组织的分类层次结构。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30b7/3965082/11f3d02bcdaf/gkt1264f1p.jpg

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