Mehta R, Petrova A
Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA.
J Perinatol. 2014 Mar;34(3):220-2. doi: 10.1038/jp.2013.151. Epub 2013 Dec 5.
As the antioxidant properties of human milk may be beneficial for very preterm-born infants, it is important to identify the association between total antioxidant capacity (TAC) and bio-active proteins.
Breast milk was prospectively collected (four times) on postpartum days 6 to 8, 13 to 15, 20 to 22 and 27 to 29 from 15 mothers who had delivered between 24 and 31 weeks of gestation. Skimmed milk was assayed to measure TAC and bio-active proteins (lysozyme, lactoferrin, leptin and adiponectin). The association between TAC and levels of bio-active proteins during the first month of lactation was analyzed in a regression model.
Coefficient of determinations (R(2)) revealed an overall effect of bio-active proteins on breast milk TAC (R(2)=0.635+/-0.102, P<0.0001). Breast milk leptin, lysozyme and lactoferrin levels were identified as independent factors that significantly predict the concentration of TAC.
The identified enhancement of the antioxidant capacity of human milk by bio-active proteins that are lacking in commercial formula supports consideration of breast milk as ideal nutrition for preterm-born neonates.
由于人乳的抗氧化特性可能对极早产婴儿有益，因此确定总抗氧化能力（TAC）与生物活性蛋白之间的关联非常重要。
前瞻性收集了15名妊娠24至31周分娩的母亲产后第6至8天、13至15天、20至22天和27至29天的母乳（共四次）。对脱脂乳进行检测以测量TAC和生物活性蛋白（溶菌酶、乳铁蛋白、瘦素和脂联素）。在回归模型中分析了哺乳期第一个月TAC与生物活性蛋白水平之间的关联。
决定系数（R²）显示生物活性蛋白对母乳TAC有总体影响（R² = 0.635 ± 0.102，P < 0.0001）。母乳中瘦素、溶菌酶和乳铁蛋白水平被确定为显著预测TAC浓度的独立因素。
已确定商业配方奶粉中缺乏的生物活性蛋白可增强人乳的抗氧化能力，这支持将母乳视为早产新生儿的理想营养来源。
