Child and Adolescent Psychiatry, KU Leuven, 3000 Leuven, Belgium.
Science. 2013 Dec 6;342(6163):1251-4. doi: 10.1126/science.1244333.
Dyslexia is a severe and persistent reading and spelling disorder caused by impairment in the ability to manipulate speech sounds. We combined functional magnetic resonance brain imaging with multivoxel pattern analysis and functional and structural connectivity analysis in an effort to disentangle whether dyslexics' phonological deficits are caused by poor quality of the phonetic representations or by difficulties in accessing intact phonetic representations. We found that phonetic representations are hosted bilaterally in primary and secondary auditory cortices and that their neural quality (in terms of robustness and distinctness) is intact in adults with dyslexia. However, the functional and structural connectivity between the bilateral auditory cortices and the left inferior frontal gyrus (a region involved in higher-level phonological processing) is significantly hampered in dyslexics, suggesting deficient access to otherwise intact phonetic representations.
阅读障碍是一种严重且持久的阅读和拼写障碍，由言语声音处理能力受损引起。我们结合功能磁共振脑成像与多元模式分析以及功能和结构连接分析，努力厘清阅读障碍者的语音缺陷是由语音表征质量差引起，还是由无法获得完整的语音表征引起。我们发现，语音表征双侧定位于初级和次级听觉皮层，其神经质量（稳健性和独特性）在阅读障碍者中是完整的。然而，双侧听觉皮层与左侧下额回（一个参与高级语音处理的区域）之间的功能和结构连接在阅读障碍者中显著受阻，表明无法访问原本完整的语音表征。
