白藜芦醇和钒对链脲佐菌素诱导的糖尿病大鼠糖尿病相关血脂异常和高血糖影响的比较
Comparison of effect of resveratrol and vanadium on diabetes related dyslipidemia and hyperglycemia in streptozotocin induced diabetic rats.
作者信息
Mohamad Shahi Majid, Haidari Fatemeh, Shiri Mohamad Reza
机构信息
Nutrition Research Center, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran.
出版信息
Adv Pharm Bull. 2011;1(2):81-6. doi: 10.5681/apb.2011.012. Epub 2011 Dec 15.
PURPOSE
Resveratrol a natural polyphenolicstilbene derivative has wide variety of biological activities. There is also a large body of evidence demonstrating positive effect of resveratrol in treatment of various metabolic complications including metabolic syndrome, obesity, diabetes and dyslipidemia in adults. The purpose of this study was to investigate anti-hyperglycemic and anti-dyslipidemic effects of resveratrol.
METHODS
We used 40 diabetic streptozotocin Wistar rats. Rats were randomly divided into 5 treatment groups (n=8 in each) including normal control, normal treated with resveratrol, diabetic control, diabetic treated with vanadium , diabetic treated with resveratrol . Resveratrol (25 mg/kgbw) and vanadate (0.2 mg/kgbw) was orally gavaged for 40 days and blood samples were directly collected from heart.
RESULTS
Diabetic rats treated with resveratrol in comparison to control diabetic rats demonstrated a significant (p = 0.001) decline in serum glucose concentration, and high plasma concentrations of total cholesterol and LDL-c were reduced (p = 0.031, p = 0.004 respectively). Furthermore, body weight loss trend that observed in diabetic rats alleviated by resveratrol and vanadate. However triglyceride, VLDL-c and HDL-c levels did not changed significantly.
CONCLUSION
In conclusion Resveratrol ameliorated dyslipidemia and hyperglycemia in diabetic rats. However further investigations in peculiar human studies are required.
目的
白藜芦醇是一种天然的多酚芪衍生物，具有多种生物活性。也有大量证据表明白藜芦醇在治疗包括成人代谢综合征、肥胖症、糖尿病和血脂异常在内的各种代谢并发症方面具有积极作用。本研究的目的是调查白藜芦醇的抗高血糖和抗血脂异常作用。
方法
我们使用了40只链脲佐菌素诱导的糖尿病Wistar大鼠。大鼠被随机分为5个治疗组（每组n = 8），包括正常对照组、白藜芦醇治疗的正常组、糖尿病对照组、钒治疗的糖尿病组、白藜芦醇治疗的糖尿病组。白藜芦醇（25mg/kg体重）和钒酸盐（0.2mg/kg体重）经口灌胃40天，直接从心脏采集血样。
结果
与糖尿病对照大鼠相比，白藜芦醇治疗的糖尿病大鼠血清葡萄糖浓度显著下降（p = 0.001），总胆固醇和低密度脂蛋白胆固醇的血浆浓度升高（分别为p = 0.031，p = 0.004）。此外，白藜芦醇和钒酸盐缓解了糖尿病大鼠体重减轻的趋势。然而，甘油三酯、极低密度脂蛋白胆固醇和高密度脂蛋白胆固醇水平没有显著变化。
结论
总之，白藜芦醇改善了糖尿病大鼠的血脂异常和高血糖。然而，需要在特殊的人体研究中进一步调查。
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