• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Evaluation of the effect of CaCl2 and alginate concentrations and hardening time on the characteristics of Lactobacillus acidophilus loaded alginate beads using response surface analysis.利用响应面分析法评估氯化钙和海藻酸钠浓度以及硬化时间对负载嗜酸乳杆菌的海藻酸钠微球特性的影响。
Adv Pharm Bull. 2012;2(1):71-8. doi: 10.5681/apb.2012.010. Epub 2012 Mar 15.
2
Preparation and characterization of alginate and psyllium beads containing Lactobacillus acidophilus.含嗜酸乳杆菌的海藻酸盐和车前草籽胶珠的制备与表征
ScientificWorldJournal. 2012;2012:680108. doi: 10.1100/2012/680108. Epub 2012 May 2.
3
Evaluation of the Effect of Psyllium on the Viability of in Alginate-Polyl Lysine Beads.评估车前草对藻酸盐-聚赖氨酸微球中[具体物质]活力的影响。 （原文中“in Alginate-Polyl Lysine Beads”前少了具体物质，翻译时补充了“[具体物质]”使句子完整通顺）
Adv Pharm Bull. 2016 Sep;6(3):337-343. doi: 10.15171/apb.2016.045. Epub 2016 Sep 25.
4
Effect of Eudragit S100 nanoparticles and alginate chitosan encapsulation on the viability of Lactobacillus acidophilus and Lactobacillus rhamnosus.聚丙烯酸树脂S100纳米颗粒及海藻酸钠-壳聚糖包封对嗜酸乳杆菌和鼠李糖乳杆菌活力的影响
AMB Express. 2017 Dec;7(1):144. doi: 10.1186/s13568-017-0442-x. Epub 2017 Jul 6.
5
Preparation and characterization of alginate and gelatin microcapsules containing Lactobacillus rhamnosus.含有鼠李糖乳杆菌的海藻酸盐和明胶微胶囊的制备与表征
An Acad Bras Cienc. 2017 Jul-Sep;89(3):1601-1613. doi: 10.1590/0001-3765201720170071. Epub 2017 Aug 31.
6
Encapsulation of Lactobacillus kefiri in alginate microbeads using a double novel aerosol technique.采用双重新型气溶胶技术将开菲尔乳杆菌包封于海藻酸钠微珠中。
Mater Sci Eng C Mater Biol Appl. 2017 Aug 1;77:548-555. doi: 10.1016/j.msec.2017.04.010. Epub 2017 Apr 3.
7
Novel solvent-based method for preparation of alginate beads with improved roundness and predictable size.用于制备具有改善的圆度和可预测尺寸的藻酸盐珠粒的新型溶剂基方法。
J Microencapsul. 2004 Dec;21(8):865-76. doi: 10.1080/02652040400015478.
8
Characterization of calcium alginate beads containing structurally similar drugs.含有结构相似药物的海藻酸钙珠的表征
Drug Dev Ind Pharm. 2006 Jun;32(5):623-33. doi: 10.1080/03639040600599863.
9
Porous Clay Heterostructure with Alginate Encapsulation for Toluene Removal.具有藻酸盐封装的多孔粘土异质结构用于甲苯去除
Nanomaterials (Basel). 2021 Feb 3;11(2):388. doi: 10.3390/nano11020388.
10
The effect of polymer and CaCl concentrations on the sulfasalazine release from alginate-N,O-carboxymethyl chitosan beads.聚合物和氯化钙浓度对柳氮磺胺吡啶从海藻酸钠-N,O-羧甲基壳聚糖微球中释放的影响。
Prog Biomater. 2013 Apr 4;2(1):10. doi: 10.1186/2194-0517-2-10.

引用本文的文献

1
Gellan Fluid Gel Embedded in Alginate Bead System: A New System for Encapsulation of and Its Application in Sour Cherry Juice.结冷胶流体凝胶包埋于海藻酸钠珠系统：一种用于包封……的新系统及其在酸樱桃汁中的应用
Food Sci Nutr. 2025 May 14;13(5):e70199. doi: 10.1002/fsn3.70199. eCollection 2025 May.
2
Enhancing Viability of GG and Total Polyphenol Content in Fermented Black Goji Berry Beverage Through Calcium-Alginate Encapsulation with Hydrocolloids.通过水胶体的海藻酸钙包封提高发酵黑枸杞饮料中枸杞的活力和总多酚含量
Foods. 2025 Feb 6;14(3):518. doi: 10.3390/foods14030518.
3
Physicochemical Properties, Drug Release and In Situ Depot-Forming Behaviors of Alginate Hydrogel Containing Poorly Water-Soluble Aripiprazole.含难溶性阿立哌唑的海藻酸盐水凝胶的物理化学性质、药物释放及原位成 depot 行为
Gels. 2024 Nov 29;10(12):781. doi: 10.3390/gels10120781.
4
Preparation of Microcapsules and Biocontrol of Cucumber Powdery Mildew.微胶囊的制备及其对黄瓜白粉病的生物防治
Microbiol Spectr. 2023 Jun 15;11(3):e0508422. doi: 10.1128/spectrum.05084-22. Epub 2023 Apr 27.
5
Sodium Alginate-Natural Microencapsulation Material of Polymeric Microparticles.海藻酸钠-聚合物微球的天然微胶囊材料。
Int J Mol Sci. 2022 Oct 11;23(20):12108. doi: 10.3390/ijms232012108.
6
Preparation and Characteristics of Alginate Microparticles for Food, Pharmaceutical and Cosmetic Applications.用于食品、制药和化妆品应用的海藻酸盐微粒的制备与特性
Polymers (Basel). 2022 Sep 14;14(18):3834. doi: 10.3390/polym14183834.
7
Monothetic Analysis and Response Surface Methodology Optimization of Calcium Alginate Microcapsules Characteristics.海藻酸钙微胶囊特性的单指标分析与响应面法优化
Polymers (Basel). 2022 Feb 12;14(4):709. doi: 10.3390/polym14040709.
8
Current Trends in Advanced Alginate-Based Wound Dressings for Chronic Wounds.用于慢性伤口的先进海藻酸盐基伤口敷料的当前趋势
J Pers Med. 2021 Sep 7;11(9):890. doi: 10.3390/jpm11090890.
9
Targeted Delivery of Probiotics: Perspectives on Research and Commercialization.靶向递送益生菌：研究与商业化的视角。
Probiotics Antimicrob Proteins. 2022 Feb;14(1):15-48. doi: 10.1007/s12602-021-09791-7. Epub 2021 Apr 27.
10
Chitosan-Coated Alginate Microcapsules Loaded with Herbal galactagogue Extract: Formulation Optimization and Characterization.负载草药催乳提取物的壳聚糖包衣藻酸盐微胶囊：配方优化与表征
Iran J Pharm Res. 2019 Summer;18(3):1180-1195. doi: 10.22037/ijpr.2019.1100776.

本文引用的文献

1
Microencapsulation of a probiotic and prebiotic in alginate-chitosan capsules improves survival in simulated gastro-intestinal conditions.微胶囊化的益生菌和益生元在海藻酸钠-壳聚糖胶囊中提高了在模拟胃肠条件下的存活率。
Int J Food Microbiol. 2010 Aug 15;142(1-2):185-9. doi: 10.1016/j.ijfoodmicro.2010.06.022. Epub 2010 Jun 30.
2
Artificial cell microcapsule for oral delivery of live bacterial cells for therapy: design, preparation, and in-vitro characterization.用于口服递送活细菌细胞进行治疗的人工细胞微胶囊：设计、制备及体外表征
J Pharm Pharm Sci. 2004 Sep 24;7(3):315-24.
3
Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics.炎症性肠病中肠道微生物群的治疗性调控：抗生素、益生菌和益生元。
Gastroenterology. 2004 May;126(6):1620-33. doi: 10.1053/j.gastro.2004.03.024.
4
An improved method of microencapsulation and its evaluation to protect Lactobacillus spp. in simulated gastric conditions.一种改进的微囊化方法及其在模拟胃部条件下对乳酸杆菌属的保护作用评估。
J Microbiol Methods. 2004 Jan;56(1):27-35. doi: 10.1016/j.mimet.2003.09.002.
5
Microencapsulation of probiotic bacteria: technology and potential applications.益生菌的微胶囊化：技术与潜在应用
Curr Issues Intest Microbiol. 2002 Sep;3(2):39-48.
6
Some probiotic properties of yeast isolates from infant faeces and Feta cheese.从婴儿粪便和费塔奶酪中分离出的酵母的一些益生菌特性。
Int J Food Microbiol. 2001 Sep 19;69(1-2):125-33. doi: 10.1016/s0168-1605(01)00580-3.
7
Encapsulation of probiotic bacteria with alginate-starch and evaluation of survival in simulated gastrointestinal conditions and in yoghurt.用海藻酸钠-淀粉对益生菌进行包封，并评估其在模拟胃肠道条件和酸奶中的存活率。
Int J Food Microbiol. 2000 Dec 5;62(1-2):47-55. doi: 10.1016/s0168-1605(00)00380-9.
8
Consumption of fermented and nonfermented dairy products: effects on cholesterol concentrations and metabolism.发酵乳制品和非发酵乳制品的消费：对胆固醇浓度和代谢的影响。
Am J Clin Nutr. 2000 Mar;71(3):674-81. doi: 10.1093/ajcn/71.3.674.
9
Lactobacillus acidophilus as a dietary adjunct for milk to aid lactose digestion in humans.嗜酸乳杆菌作为一种添加到牛奶中的膳食辅助成分，以帮助人体消化乳糖。
J Dairy Sci. 1983 May;66(5):959-66. doi: 10.3168/jds.S0022-0302(83)81887-6.

利用响应面分析法评估氯化钙和海藻酸钠浓度以及硬化时间对负载嗜酸乳杆菌的海藻酸钠微球特性的影响。

Evaluation of the effect of CaCl2 and alginate concentrations and hardening time on the characteristics of Lactobacillus acidophilus loaded alginate beads using response surface analysis.

作者信息

Lotfipour Farzaneh, Mirzaeei Shahla, Maghsoodi Maryam

机构信息

Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. ; Gastrointestinal and Liver Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Adv Pharm Bull. 2012;2(1):71-8. doi: 10.5681/apb.2012.010. Epub 2012 Mar 15.

DOI:10.5681/apb.2012.010
PMID:24312773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3846017/
Abstract

PURPOSE

This article describes preparation and characterization of beads of alginate containing probiotic bacteria of Lactobacillus acidophilus DMSZ20079.

METHODS

Fourteen formulations using different alginate (ALG) and CaCl2 concentrations as well as hardening times were prepared using extrusion technique. The prepared beads were characterized in terms of size, morphology, encapsulation efficiency and bacterial viabilities in acid (pH 1.8, 2 hours) condition.

RESULTS

The results showed that spherical beads with narrow size distribution ranging from 1.32±0.04 to 1.70±0.07 mm were achieved with encapsulation efficiency higher than 98%. Surface response analysis revealed that alginate concentration was the important factor for the size, shape and encapsulation efficiency of prepared beads. Furthermore, survived bacteria after acid exposure in all prepared beads (63-83%) were significantly higher than those of untreated cells (39%) and enhanced by increasing alginate concentration. Surface response analysis revealed that the effect of all three factors of alginate and CaCl2 concentrations as well as hardening times were significant in acid viability, however alginate concentration played the most important role according to its regression coefficient.

CONCLUSION

Among alginate and CaCl2 concentrations as well as hardening times, alginate concentration was the most variable in the characteristics of Alginate beads.

摘要

目的

本文描述了含嗜酸乳杆菌DMSZ20079益生菌的海藻酸盐微球的制备及表征。

方法

采用挤压技术制备了14种不同海藻酸盐（ALG）和氯化钙浓度以及硬化时间的配方。对制备的微球进行了尺寸、形态、包封效率和在酸性（pH 1.8，2小时）条件下的细菌活力表征。

结果

结果表明，获得了尺寸分布窄的球形微球，直径范围为1.32±0.04至1.70±0.07毫米，包封效率高于98%。表面响应分析表明，海藻酸盐浓度是影响制备微球尺寸、形状和包封效率的重要因素。此外，所有制备微球在酸处理后存活的细菌（63 - 83%）显著高于未处理细胞（39%），且随着海藻酸盐浓度的增加而提高。表面响应分析表明，海藻酸盐和氯化钙浓度以及硬化时间这三个因素对酸处理后的细菌活力均有显著影响，但根据回归系数，海藻酸盐浓度起最重要作用。

结论

在海藻酸盐和氯化钙浓度以及硬化时间中，海藻酸盐浓度对海藻酸盐微球特性的影响最为显著。