Fathiazad Fatemeh, Hamedeyazdan Sanaz, Khosropanah Mohamad Karim, Khaki Arash
Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Iran.
Adv Pharm Bull. 2013;3(1):207-10. doi: 10.5681/apb.2013.034. Epub 2013 Feb 7.
Fumaria parviflora Lam (Fumariaceae) has been used in traditional medicine in the treatment of several diseases such as diabetes. The present work was designed to evaluate the hypoglycaemic effects of methanolic extract (ME) of F. parviflora in normal and streptozotocin-induced diabetic rats.
The rats used were allocated in six (I, II, III, IV, V and VI) experimental groups (n=5). Group I rats served as 'normal control' animals received distilled water and group II rats served as 'diabetic control' animals. Diabetes mellitus was induced in groups II, V and VI rats by intraperitoneal single injection of streptozotocin (STZ, 55 mg kg-1). Group V and VI rats were addi-tionally treated with ME (150 mg kg-1 day-1 and 250 mg kg-1 day-1, i.p. respectively) 24 hour post STZ injection, for seven consecutive days. Groups III and IV rats received only ME 150 mg kg-1 day-1 and 250 mg kg-1 day-1, i.p. respectively for seven days. The levels of blood glucose were determined using a Glucometer.
Administra-tion of F. parviflora extract showed a potent glucose lowering effect only on streptozo-tocin (STZ) induced diabetic rats below 100 mg/dl (P<0.001). However, no significant differences in the blood glucose levels were recorded between diabetic rats received 125 or 250 mg/kg of plant extracts.
The findings of the study indicated that F. parviflora has significant hypoglycemic effect on STZ-induced diabetic rats with no effects on blood glucose levels of normal rats.
小花烟堇（紫堇科）在传统医学中被用于治疗多种疾病，如糖尿病。本研究旨在评估小花烟堇甲醇提取物（ME）对正常大鼠和链脲佐菌素诱导的糖尿病大鼠的降血糖作用。
将所用大鼠分为六个（I、II、III、IV、V和VI）实验组（n = 5）。I组大鼠作为“正常对照”动物，给予蒸馏水，II组大鼠作为“糖尿病对照”动物。通过腹腔单次注射链脲佐菌素（STZ，55 mg/kg）诱导II、V和VI组大鼠患糖尿病。在注射STZ 24小时后，V组和VI组大鼠分别连续7天额外接受ME（分别为150 mg/kg/天和250 mg/kg/天，腹腔注射）治疗。III组和IV组大鼠分别连续7天仅腹腔注射150 mg/kg/天和250 mg/kg/天的ME。使用血糖仪测定血糖水平。
小花烟堇提取物仅对链脲佐菌素（STZ）诱导的糖尿病大鼠（血糖低于100 mg/dl）有显著的降糖作用（P<0.001）。然而，接受125或250 mg/kg植物提取物的糖尿病大鼠之间的血糖水平没有显著差异。
该研究结果表明，小花烟堇对STZ诱导的糖尿病大鼠有显著的降血糖作用，对正常大鼠的血糖水平无影响。
