El-Shal Manal A
National Organization for Drug Control and Research (NODCAR), Pyramid Ave., P. O. B 29 Cairo, Egypt.
Adv Pharm Bull. 2013;3(2):339-44. doi: 10.5681/apb.2013.055. Epub 2013 Aug 20.
Cyclic voltammetry and differential pulse voltammetry were used to explore the diffusion behavior of two antipsychotic drugs at a glassy carbon electrode. A well-defined oxidation peak was obtained in Britton-Robinson (BR) buffer (pH 2.0). The response was evaluated as a function of some variables such as the scan rate, and pH.
A simple, precise, inexpensive and sensitive voltammetric method has been developed for the determination of the cited drugs Olanzapine (OLZ) and Quetiapine fumarate (QUT).
A linear calibration was obtained from 3 × 10(-8) M to 4 × 10(-6) M and 2 × 10(-8) M to 5 × 10(-6) M, with R. S. D. were 1.6 % and 1.2 % for OLZ and QUT, respectively. The limit of detection (LOD) was 1 × 10(-8) M, while the limit of quantification (LOQ) was 3 × 10(-8) M.
The method was applied to the determination of investigated drugs in urine and serum samples and dosage forms.
采用循环伏安法和差分脉冲伏安法研究两种抗精神病药物在玻碳电极上的扩散行为。在 Britton-Robinson（BR）缓冲液（pH 2.0）中获得了明确的氧化峰。考察了扫描速率和 pH 等变量对响应的影响。
建立了一种简单、准确、廉价且灵敏的伏安法，用于测定奥氮平（OLZ）和富马酸喹硫平（QUT）。
线性校准范围分别为 3×10⁻⁸ M 至 4×10⁻⁶ M 和 2×10⁻⁸ M 至 5×10⁻⁶ M，奥氮平和富马酸喹硫平的相对标准偏差分别为 1.6%和 1.2%。检测限（LOD）为 1×10⁻⁸ M，定量限（LOQ）为 3×10⁻⁸ M。
该方法应用于尿液、血清样品及剂型中被测药物的测定。
