Parhizkar Saadat, Yusoff Maryam Jamielah, Dollah Mohammad Aziz
Medicinal Plants Research Centre, Yasuj University of Medical Sciences (YUMS), Yasuj, Iran.
Adv Pharm Bull. 2013;3(2):345-52. doi: 10.5681/apb.2013.056. Epub 2013 Aug 20.
The purpose of this study was to determine the effects of Phaleria macrocarpa (PM) on male fertility by assessing its effect on the sperm characteristics which included the sperm count, motility, viability and morphology.
Eighteen male rats were equally divided into three groups. Each group of rats was orally supplemented for 7 weeks either with PM aqueous extract (240 mg/kg), distilled water (0 mg/kg) or testosterone hormone, Andriol® Testocaps™ (4 mg/kg) respectively. On the last day of supplementation period, the rats were sacrificed and sperm was obtained from cauda epididymis via orchidectomy. The sperm count, motility, viability and morphology were determined.
PM aqueous extract significantly increased (p<0.05) the percentage of sperm viability. However, there was no significant effect of PM on the percentage of both sperm motility and morphology. The mean of body weight declined significantly in rats supplemented with PM aqueous extract compared to control groups (p<0.05).
The results showed that PM significantly increased sperm viability without changing the sperm motility and morphology. Hence, this study suggests that PM offers an alternative way to improve male fertility by improving the sperm quality.
本研究旨在通过评估大果紫檀（PM）对精子特征（包括精子数量、活力、存活率和形态）的影响，来确定其对雄性生育能力的作用。
将18只雄性大鼠平均分为三组。每组大鼠分别口服补充7周的PM水提取物（240毫克/千克）、蒸馏水（0毫克/千克）或睾酮激素安特尔胶囊（4毫克/千克）。在补充期的最后一天，处死大鼠，通过睾丸切除术从附睾尾部获取精子。测定精子数量、活力、存活率和形态。
PM水提取物显著提高了精子存活率（p<0.05）。然而，PM对精子活力和形态的百分比没有显著影响。与对照组相比，补充PM水提取物的大鼠体重平均值显著下降（p<0.05）。
结果表明，PM显著提高了精子存活率，而不改变精子活力和形态。因此，本研究表明，PM通过改善精子质量为提高雄性生育能力提供了一种替代方法。
