Wu Wen-Ming, Zhu Yun-Yun, Li Hao-Ran, Yu Heng-Yi, Zhang Peng, Pi Hui-Fang, Ruan Han-Li
a Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Faculty of Pharmacy, Tongji Medical College of Huazhong University of Science and Technology , Wuhan , 430030 , China.
J Asian Nat Prod Res. 2014;16(2):192-9. doi: 10.1080/10286020.2013.864639. Epub 2013 Dec 6.
Two new alkaloids, lycosprenine (1) and 2α-methoxy-6-O-methyllycorenine (2), along with 22 known alkaloids (3-23b), were isolated from the bulb of Lycoris sprengeri. Their structures were elucidated on the basis of spectral analysis and by comparison of the spectroscopic data with those of known compounds. Selected compounds (1-3 and 6-9) were tested for their neuroprotective activities against H2O2-, CoCl2- and Aβ25-35-induced SH-SY5Y cell injury, most of which exhibited neuroprotective effects of different degrees.
从换锦花的鳞茎中分离出两种新生物碱，即石蒜碱（1）和2α-甲氧基-6-O-甲基石蒜宁碱（2），以及22种已知生物碱（3 - 23b）。通过光谱分析并将光谱数据与已知化合物的数据进行比较，阐明了它们的结构。对选定的化合物（1 - 3和6 - 9）针对H2O2、CoCl2和Aβ25 - 35诱导的SH - SY5Y细胞损伤的神经保护活性进行了测试，其中大多数表现出不同程度的神经保护作用。
