疼痛、非医疗处方类阿片类药物使用与药物过量史之间的关联。
Associations among pain, non-medical prescription opioid use, and drug overdose history.
机构信息
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan.
出版信息
Am J Addict. 2014 Jan-Feb;23(1):41-7. doi: 10.1111/j.1521-0391.2013.12055.x. Epub 2013 Jun 14.
Abstract
BACKGROUND AND OBJECTIVE
Recently, use of prescription opioids (POs) has increased; non-medical PO (NMPO) use is linked to overdose. NMPO use is common among individuals prescribed opioids for pain, and those in substance use disorder (SUD) treatment with pain could be at increased risk for unintentional overdose due to NMPO use. We examined associations between pain, NMPO use, and overdose among SUD treatment patients.
METHODS
Among 342 patients at a residential SUD treatment center, logistic regression examined the association of overdose with pain, adjusting for substance use, suicide attempts, and demographics.
RESULTS
Pain was positively related to NMPO use. Heroin use, suicide attempts, pain, and NMPO use were positively associated with overdose; but NMPO use attenuated the pain-overdose relationship.
CONCLUSIONS
The relationship between pain and overdose among substance users may be, in part, explained by the association between pain and heavy NMPO use.
摘要
背景和目的
最近，处方类阿片（POs）的使用有所增加；非医疗用途 PO（NMPO）的使用与过量有关。在因疼痛而开处方使用阿片类药物的人群和接受物质使用障碍（SUD）治疗伴有疼痛的人群中，NMPO 的使用较为常见，由于 NMPO 的使用，这些人可能有更高的意外过量风险。我们研究了 SUD 治疗患者中疼痛、NMPO 使用与过量之间的关联。
方法
在一家住院 SUD 治疗中心的 342 名患者中，使用逻辑回归检验了疼痛与过量之间的关联，同时调整了物质使用、自杀企图和人口统计学因素。
结果
疼痛与 NMPO 使用呈正相关。海洛因使用、自杀企图、疼痛和 NMPO 使用与过量呈正相关；但 NMPO 使用减弱了疼痛与过量之间的关系。
结论
在物质使用者中，疼痛与过量之间的关系可能部分解释为疼痛与大量 NMPO 使用之间的关联。
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