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向基底核大细胞部区域注射P物质可促进抑制性回避任务的表现。

Substance P injected into the region of the nucleus basalis magnocellularis facilitates performance of an inhibitory avoidance task.

作者信息

Kafetzopoulos E, Holzhäuer M S, Huston J P

出版信息

Psychopharmacology (Berl). 1986;90(2):281-3. doi: 10.1007/BF00181260.

DOI:10.1007/BF00181260
PMID:2431428
Abstract

The neuropeptide substance P (SP) was injected into the region of the nucleus basalis magnocellularis (NBM). The influence of SP on the performance of the single trial "uphill avoidance task" was tested. The post-trial injection of 1 ng SP (in 0.5 microliter volume) led to significantly longer latencies in the uphill response. This result can be interpreted in terms of a facilitating effect of SP on performance of an inhibitory avoidance response.

摘要

将神经肽P物质（SP）注射到基底大细胞核（NBM）区域。测试了SP对单次试验“上坡回避任务”表现的影响。试验后注射1纳克SP（体积为0.5微升）导致上坡反应的潜伏期显著延长。这一结果可以解释为SP对抑制性回避反应表现具有促进作用。

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The cholinergic hypothesis of geriatric memory dysfunction.老年记忆功能障碍的胆碱能假说。
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