Stäubli U, Huston J P
Behav Brain Res. 1980 Jun;1(3):245-55. doi: 10.1016/0166-4328(80)90032-7.
The undeca-neuropeptide substance P (SP) was injected post-trial into the medial nucleus of the septum to test its influence on passive avoidance learning in rats. A facilitation of learning was attained in the alcove avoidance task with doses of 50 ng (37 pmol), 500 ng (370 pmol) and 6.7 microgram (5 nmol) SP and in the step-up avoidance task with 500 ng and 6.7 microgram SP. In the step-down avoidance task no influence of SP was discernible, probably as a consequence of the high retention shown by control animals, masking a possible SP-induced facilitation of learning (ceiling effect). Interestingly, in its effect on learning, SP applied in the septum imitates the effect of electrical septal stimulation, thus providing another example for the parallelism between post-trial SP and electrical brain stimulation which we have demonstrated previously in the substantia nigra, amygdala and lateral hypothalamus.
在试验后将十一肽神经肽P物质（SP）注射到隔内侧核，以测试其对大鼠被动回避学习的影响。在壁龛回避任务中，50纳克（37皮摩尔）、500纳克（370皮摩尔）和6.7微克（5纳摩尔）的SP剂量可促进学习；在逐步回避任务中，500纳克和6.7微克的SP也有此作用。在逐步下降回避任务中，未发现SP有影响，这可能是由于对照动物表现出的高保持率掩盖了SP可能诱导的学习促进作用（天花板效应）。有趣的是，在对学习的影响方面，应用于隔区的SP模仿了隔区电刺激的效果，从而为试验后SP与脑电刺激之间的平行关系提供了另一个例子，我们之前已在黑质、杏仁核和下丘脑外侧核中证明了这种平行关系。
