Stäubli U, Huston J P
Behav Neural Biol. 1985 Jan;43(1):100-8. doi: 10.1016/s0163-1047(85)91538-9.
A series of studies had revealed a dualistic role of post-trial injections of substance P in affecting avoidance behavior depending on the site of the brain in which it is applied. Based on these data, the hypothesis was formulated that substance P has brain site-dependent rewarding and punishing properties, a possibility which was assessed in rats trained on a modified T-maze task. Injections of substance P into the medial forebrain bundle (100 ng) or medial septal nucleus (500 ng) served as a positive reinforcer for conditioned place preference learning in the T maze. Injections into the amygdala (50 ng) or substantia nigra (100 ng) did not have such reinforcing properties.
一系列研究揭示了试验后注射P物质对回避行为的双重作用，这取决于其在大脑中应用的部位。基于这些数据，提出了一个假设，即P物质具有脑区依赖性的奖赏和惩罚特性，这一可能性在经过改良T迷宫任务训练的大鼠中进行了评估。向内侧前脑束注射P物质（100纳克）或内侧隔核（500纳克）可作为T迷宫中条件性位置偏好学习的阳性强化物。向杏仁核（50纳克）或黑质（100纳克）注射则不具有这种强化特性。
