Cerrahpaşa Medical Faculty, Department of Dermatology, İstanbul University, İstanbul, Turkey.
Clin Dermatol. 2014 Jan-Feb;32(1):35-46. doi: 10.1016/j.clindermatol.2013.05.024.
Rosacea is a common and chronic inflammatory cutaneous disease with unknown etiology. The pathophysiology of rosacea is still poorly understood. Epidemiological studies indicate a genetic component, but a rosacea gene has not been detected yet. Recent molecular studies propose that an altered innate immune response is involved in the pathogenesis of the rosacea disease. Signs of rosacea are indicated by the presence of characteristic facial or ocular inflammation involving both the vascular and tissue stroma. A wide range of drug options is available for the treatment of rosacea, including several topical ones (metronidazole, antibiotics, azelaic acid, benzoyl peroxide, sulfacetamide/sulfur, retinoids) and oral ones (mainly tetracyclines, metronidazole, macrolides, isotretinoin). This review highlights the recent clinical and pathophysiological developments concerning rosacea.
酒渣鼻是一种常见的慢性炎症性皮肤疾病，病因不明。酒渣鼻的病理生理学仍知之甚少。流行病学研究表明存在遗传成分，但尚未发现酒渣鼻基因。最近的分子研究表明，先天免疫反应的改变与酒渣鼻疾病的发病机制有关。酒渣鼻的特征是存在特征性的面部或眼部炎症，涉及血管和组织基质。有多种药物可供治疗酒渣鼻，包括几种局部药物（甲硝唑、抗生素、壬二酸、过氧化苯甲酰、磺胺醋酰/硫磺、类视黄醇）和口服药物（主要为四环素类、甲硝唑、大环内酯类、异维 A 酸）。这篇综述强调了酒渣鼻最近的临床和病理生理学进展。
