Daar A S
Dalla Lana School of Public Health and Department of Surgery, University of Toronto, Ontario, Canada; Sandra Rotman Centre, University Health Network and University of Toronto, Ontario, Canada.
Transplant Proc. 2013;45(10):3450-2. doi: 10.1016/j.transproceed.2013.09.011.
As we continue to have severe shortages of organs for transplantation, we need to consider alternatives for the future. The most likely to make a real difference in the long term is regenerative medicine (RM), a field that has emerged from the conjunction of stem cell biology and cell therapies; gene therapy; biomaterials and tissue engineering; and organ transplantation. Transplantation and RM share the same essential goal: to replace or restore organ function. Herein I briefly review some major breakthroughs of RM that are relevant to the future of organ transplantation, with a focus on the needs of people in the developing world. A definition of RM is provided and the ethical, legal, and social issues are briefly highlighted. In conclusion, I provide a projection of what the future may be for RM.
由于我们持续面临移植器官严重短缺的问题，我们需要考虑未来的替代方案。从长远来看，最有可能带来实质性改变的是再生医学（RM），这一领域是干细胞生物学与细胞疗法、基因疗法、生物材料与组织工程以及器官移植相结合而产生的。移植和再生医学有着相同的基本目标：替代或恢复器官功能。在此，我简要回顾一些与器官移植未来相关的再生医学重大突破，重点关注发展中世界人民的需求。文中给出了再生医学的定义，并简要强调了伦理、法律和社会问题。最后，我对再生医学的未来发展进行了展望。
