Yoshitake Kohei, Tsukano Hiroaki, Tohmi Manavu, Komagata Seiji, Hishida Ryuichi, Yagi Takeshi, Shibuki Katsuei
Department of Neurophysiology, Brain Research Institute, Niigata University, 1-757 Asahi-machi, Chuo-ku, Niigata 951-8585, Japan; Japan Science and Technology Agency, CREST, 7 Goban-cho, Chiyoda-ku, Tokyo 102-0076, Japan.
Department of Neurophysiology, Brain Research Institute, Niigata University, 1-757 Asahi-machi, Chuo-ku, Niigata 951-8585, Japan.
Cell Rep. 2013 Dec 12;5(5):1365-74. doi: 10.1016/j.celrep.2013.11.006. Epub 2013 Dec 5.
Mice navigate nearby space using their vision and whiskers, and young mice learn to integrate these heterogeneous inputs in perceptual space. We found that cortical responses were depressed in the primary visual cortex of young mice after wearing a monocular prism. This depression was uniformly observed in the primary visual cortex and was eliminated by whisker trimming or lesions in the posterior parietal cortex. Compensatory visual map shifts of responses elicited via the eye that had worn the prism were also observed. As a result, cortical responses elicited via each eye were clearly separated when a visual stimulus was placed in front of the mice. A comparison of response areas before and after prism wearing indicated that the map shifts were produced by depression with spatial eccentricity. Visual map shifts based on whisker-guided cues may serve as a model for investigating the cellular and molecular mechanisms underlying higher sensory integration in the mammalian brain.
小鼠利用视觉和胡须来导航附近空间，幼鼠学会在感知空间中整合这些不同的输入信息。我们发现，幼鼠佩戴单眼棱镜后，初级视觉皮层的皮质反应受到抑制。这种抑制在初级视觉皮层中普遍观察到，并通过修剪胡须或损伤后顶叶皮层而消除。还观察到通过佩戴棱镜的眼睛引发的反应的补偿性视觉图谱移位。因此，当在小鼠面前放置视觉刺激时，通过每只眼睛引发的皮质反应明显分开。比较佩戴棱镜前后的反应区域表明，图谱移位是由具有空间偏心率的抑制产生的。基于胡须引导线索的视觉图谱移位可作为研究哺乳动物大脑中高级感觉整合潜在细胞和分子机制的模型。
