• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Combination cytotoxicity of backbone degradable HPMA copolymer gemcitabine and platinum conjugates toward human ovarian carcinoma cells.骨干可降解 HPMA 共聚物吉西他滨和铂缀合物对人卵巢癌细胞的联合细胞毒性。
Eur J Pharm Biopharm. 2014 May;87(1):187-96. doi: 10.1016/j.ejpb.2013.11.008. Epub 2013 Dec 4.
2
Biodegradable multiblock poly(N-2-hydroxypropyl)methacrylamide gemcitabine and paclitaxel conjugates for ovarian cancer cell combination treatment.可生物降解的多嵌段聚（N-2-羟丙基）甲基丙烯酰胺吉西他滨和紫杉醇缀合物用于卵巢癌细胞联合治疗。
Int J Pharm. 2013 Sep 15;454(1):435-43. doi: 10.1016/j.ijpharm.2013.06.046. Epub 2013 Jul 1.
3
Backbone Degradable N-(2-Hydroxypropyl)methacrylamide Copolymer Conjugates with Gemcitabine and Paclitaxel: Impact of Molecular Weight on Activity toward Human Ovarian Carcinoma Xenografts.具有吉西他滨和紫杉醇的主链可降解N-(2-羟丙基)甲基丙烯酰胺共聚物缀合物：分子量对人卵巢癌异种移植瘤活性的影响。
Mol Pharm. 2017 May 1;14(5):1384-1394. doi: 10.1021/acs.molpharmaceut.6b01005. Epub 2017 Feb 3.
4
Synthesis and evaluation of a backbone biodegradable multiblock HPMA copolymer nanocarrier for the systemic delivery of paclitaxel.合成与评价一种主链可生物降解的多嵌段 HPMA 共聚物纳米载体用于紫杉醇的系统给药。
J Control Release. 2013 Feb 28;166(1):66-74. doi: 10.1016/j.jconrel.2012.12.009. Epub 2012 Dec 20.
5
Sequential combination therapy of ovarian cancer with degradable N-(2-hydroxypropyl)methacrylamide copolymer paclitaxel and gemcitabine conjugates.聚 N-(2-羟丙基)甲基丙烯酰胺共聚物紫杉醇和吉西他滨缀合物序贯联合治疗卵巢癌。
Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12181-6. doi: 10.1073/pnas.1406233111. Epub 2014 Aug 4.
6
Synthesis of long-circulating, backbone degradable HPMA copolymer-doxorubicin conjugates and evaluation of molecular-weight-dependent antitumor efficacy.长循环、主链可降解 HPMA 共聚物-阿霉素偶联物的合成及其分子量依赖性抗肿瘤活性评价。
Macromol Biosci. 2013 Feb;13(2):155-60. doi: 10.1002/mabi.201200353. Epub 2013 Jan 22.
7
Combination effects of platinum drugs and N1, N11 diethylnorspermine on spermidine/spermine N1-acetyltransferase, polyamines and growth inhibition in A2780 human ovarian carcinoma cells and their oxaliplatin and cisplatin-resistant variants.铂类药物与 N1，N11-二乙基去甲精脒联合作用对人卵巢癌细胞 A2780 及其奥沙利铂和顺铂耐药株中的 spermidine/spermine N1-乙酰基转移酶、多胺和生长抑制的影响。
Cancer Chemother Pharmacol. 2011 Feb;67(2):401-14. doi: 10.1007/s00280-010-1334-9. Epub 2010 May 5.
8
Stimuli-Sensitive Biodegradable and Amphiphilic Block Copolymer-Gemcitabine Conjugates Self-Assemble into a Nanoscale Vehicle for Cancer Therapy.刺激响应性生物可降解两亲嵌段共聚物-吉西他滨偶联物自组装成用于癌症治疗的纳米级载体。
ACS Appl Mater Interfaces. 2017 Feb 1;9(4):3474-3486. doi: 10.1021/acsami.6b15232. Epub 2017 Jan 20.
9
Backbone degradable multiblock N-(2-hydroxypropyl)methacrylamide copolymer conjugates via reversible addition-fragmentation chain transfer polymerization and thiol-ene coupling reaction.通过可逆加成-断裂链转移聚合和硫醇-烯点击反应制备可降解多嵌段 N-(2-羟丙基)甲基丙烯酰胺共聚物偶联物。
Biomacromolecules. 2011 Jan 10;12(1):247-52. doi: 10.1021/bm101254e. Epub 2010 Dec 15.
10
Mechanisms of synergism between cisplatin and gemcitabine in ovarian and non-small-cell lung cancer cell lines.顺铂与吉西他滨在卵巢癌和非小细胞肺癌细胞系中的协同作用机制。
Br J Cancer. 1999 Jun;80(7):981-90. doi: 10.1038/sj.bjc.6690452.

引用本文的文献

1
Nanocarrier drug delivery systems for gynecological cancer therapeutics.用于妇科癌症治疗的纳米载体药物递送系统。
J Control Release. 2025 Sep 10;385:114028. doi: 10.1016/j.jconrel.2025.114028. Epub 2025 Jul 17.
2
Synthesis and Characterization of Polymer-Drug Conjugates by Strain-Promoted Azide-Alkyne Cycloaddition-Mediated Polymerization.通过应变促进的叠氮化物-炔烃环加成介导的聚合反应合成及表征聚合物-药物共轭物
J Appl Polym Sci. 2025 Jun 5;142(21). doi: 10.1002/app.56928. Epub 2025 Feb 24.
3
Polymer Conjugate as the New Promising Drug Delivery System for Combination Therapy against Cancer.聚合物偶联物作为联合治疗癌症的新型有前途的药物传递系统。
Curr Top Med Chem. 2024;24(13):1101-1119. doi: 10.2174/0115680266280603240321064308.
4
Stimuli-sensitive polymer prodrug nanocarriers by reversible-deactivation radical polymerization.刺激响应性聚合物前药纳米载体的可逆失活自由基聚合。
Chem Soc Rev. 2024 Jun 17;53(12):6511-6567. doi: 10.1039/d2cs01060g.
5
A lipid/PLGA nanocomplex to reshape tumor immune microenvironment for colon cancer therapy.一种用于重塑肿瘤免疫微环境以治疗结肠癌的脂质/聚乳酸-羟基乙酸共聚物纳米复合物。
Regen Biomater. 2024 Mar 28;11:rbae036. doi: 10.1093/rb/rbae036. eCollection 2024.
6
Unraveling Ros Conversion Through Enhanced Enzyme-Like Activity with Copper-Doped Cerium Oxide for Tumor Nanocatalytic Therapy.通过铜掺杂氧化铈增强的类酶活性来解开 Ros 转换，用于肿瘤纳米催化治疗。
Adv Sci (Weinh). 2024 Mar;11(11):e2307154. doi: 10.1002/advs.202307154. Epub 2023 Dec 31.
7
Enhancing drug penetration in solid tumors via nanomedicine: Evaluation models, strategies and perspectives.通过纳米药物增强实体瘤中的药物渗透：评估模型、策略与展望。
Bioact Mater. 2023 Oct 26;32:445-472. doi: 10.1016/j.bioactmat.2023.10.017. eCollection 2024 Feb.
8
Stimuli-activatable nanomedicine meets cancer theranostics.刺激响应型纳米医学与癌症诊治一体化。
Theranostics. 2023 Oct 2;13(15):5386-5417. doi: 10.7150/thno.87854. eCollection 2023.
9
GSH-sensitive polymeric prodrug: Synthesis and loading with photosensitizers as nanoscale chemo-photodynamic anti-cancer nanomedicine.谷胱甘肽敏感型聚合物前药：作为纳米级化学 - 光动力抗癌纳米药物的合成及光敏剂负载
Acta Pharm Sin B. 2022 Jan;12(1):424-436. doi: 10.1016/j.apsb.2021.05.003. Epub 2021 May 15.
10
Thermoresponsive polymeric dexamethasone prodrug for arthritis pain.用于关节炎疼痛的温敏性聚合物地塞米松前药。
J Control Release. 2021 Nov 10;339:484-497. doi: 10.1016/j.jconrel.2021.10.007. Epub 2021 Oct 12.

本文引用的文献

1
Biodegradable multiblock poly(N-2-hydroxypropyl)methacrylamide gemcitabine and paclitaxel conjugates for ovarian cancer cell combination treatment.可生物降解的多嵌段聚（N-2-羟丙基）甲基丙烯酰胺吉西他滨和紫杉醇缀合物用于卵巢癌细胞联合治疗。
Int J Pharm. 2013 Sep 15;454(1):435-43. doi: 10.1016/j.ijpharm.2013.06.046. Epub 2013 Jul 1.
2
Efficiency of high molecular weight backbone degradable HPMA copolymer-prostaglandin E1 conjugate in promotion of bone formation in ovariectomized rats.高分子量骨架可降解 HPMA 共聚物-前列腺素 E1 缀合物促进去卵巢大鼠骨形成的效率。
Biomaterials. 2013 Sep;34(27):6528-38. doi: 10.1016/j.biomaterials.2013.05.003. Epub 2013 Jun 2.
3
Synthesis of long-circulating, backbone degradable HPMA copolymer-doxorubicin conjugates and evaluation of molecular-weight-dependent antitumor efficacy.长循环、主链可降解 HPMA 共聚物-阿霉素偶联物的合成及其分子量依赖性抗肿瘤活性评价。
Macromol Biosci. 2013 Feb;13(2):155-60. doi: 10.1002/mabi.201200353. Epub 2013 Jan 22.
4
Synthesis and evaluation of a backbone biodegradable multiblock HPMA copolymer nanocarrier for the systemic delivery of paclitaxel.合成与评价一种主链可生物降解的多嵌段 HPMA 共聚物纳米载体用于紫杉醇的系统给药。
J Control Release. 2013 Feb 28;166(1):66-74. doi: 10.1016/j.jconrel.2012.12.009. Epub 2012 Dec 20.
5
Macromolecular therapeutics in cancer treatment: the EPR effect and beyond.癌症治疗中的高分子治疗学：EPR 效应及超越
J Control Release. 2012 Dec 10;164(2):138-44. doi: 10.1016/j.jconrel.2012.04.038. Epub 2012 May 1.
6
An overview of current diagnosis and treatment in ovarian cancer.卵巢癌当前诊断与治疗概述
Int J Gynecol Cancer. 2012 May;22 Suppl 1:S2-4. doi: 10.1097/IGC.0b013e318251c8e3.
7
Biodegradable Multiblock Poly[N-(2-hydroxypropyl)methacrylamide] via Reversible Addition-Fragmentation Chain Transfer Polymerization and Click Chemistry.通过可逆加成-断裂链转移聚合和点击化学制备可生物降解的多嵌段聚[N-(2-羟丙基)甲基丙烯酰胺]
Macromolecules. 2011 Apr 26;44(8):2481-2488. doi: 10.1021/ma102574e.
8
Synthesis of Biodegradable Multiblock Copolymers by Click Coupling of RAFT-Generated HeterotelechelicPolyHPMA Conjugates.通过RAFT生成的杂臂端基聚（N-（2-羟丙基）甲基丙烯酰胺）共轭物的点击偶联合成可生物降解的多嵌段共聚物。
React Funct Polym. 2011 Mar 1;71(3):294-302. doi: 10.1016/j.reactfunctpolym.2010.10.005.
9
Backbone degradable multiblock N-(2-hydroxypropyl)methacrylamide copolymer conjugates via reversible addition-fragmentation chain transfer polymerization and thiol-ene coupling reaction.通过可逆加成-断裂链转移聚合和硫醇-烯点击反应制备可降解多嵌段 N-(2-羟丙基)甲基丙烯酰胺共聚物偶联物。
Biomacromolecules. 2011 Jan 10;12(1):247-52. doi: 10.1021/bm101254e. Epub 2010 Dec 15.
10
Gemox: a widely useful therapy against solid tumors-review and personal experience.吉西他滨联合奥沙利铂方案：一种广泛应用于实体瘤治疗的方法——综述与个人经验
J Chemother. 2010 Oct;22(5):298-303. doi: 10.1179/joc.2010.22.5.298.

骨干可降解 HPMA 共聚物吉西他滨和铂缀合物对人卵巢癌细胞的联合细胞毒性。

Combination cytotoxicity of backbone degradable HPMA copolymer gemcitabine and platinum conjugates toward human ovarian carcinoma cells.

机构信息

Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA; School of Medical Sciences, University of Phayao, Phayao, Thailand.

Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA.

出版信息

Eur J Pharm Biopharm. 2014 May;87(1):187-96. doi: 10.1016/j.ejpb.2013.11.008. Epub 2013 Dec 4.

DOI:10.1016/j.ejpb.2013.11.008
PMID:24316339
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4035385/
Abstract

Multiblock, backbone degradable HPMA copolymer-drug conjugates containing gemcitabine and DACH platinum (mP-GEM and mP-DACH Pt), respectively were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization and subsequent chain extension by click chemistry. Using combination index analysis, the cytotoxicities of the two multiblock conjugates, as single agent and in combination, were evaluated in vitro in A2780 human ovarian cancer cells, with free drugs as controls. The greatest synergistic cytotoxic effect was observed when A2780 cells were sequentially exposed to mP-GEM for 24h and mP-DACH Pt for 48h. In addition, mechanistic studies support the rationale of the synergy between mP-GEM and mP-DACH Pt: mP-GEM pretreatment was able to enhance the platinum-DNA adduct accumulation and inhibit cell proliferation to a higher extent than single mP-DACH Pt treatment. These observations are useful for the development of combination macromolecular therapeutics for ovarian cancer based on the second-generation backbone degradable HPMA copolymers.

摘要

分别含有吉西他滨和 DACH 铂（mP-GEM 和 mP-DACH Pt）的多嵌段、主链可降解 HPMA 共聚物 - 药物偶联物通过可逆加成 - 断裂链转移（RAFT）聚合和随后的点击化学链延伸合成。使用组合指数分析，在 A2780 人卵巢癌细胞中，以游离药物作为对照，评估了两种多嵌段缀合物作为单一药物和联合使用的体外细胞毒性。当 A2780 细胞依次暴露于 mP-GEM 24 小时和 mP-DACH Pt 48 小时时，观察到最大的协同细胞毒性作用。此外，机制研究支持 mP-GEM 和 mP-DACH Pt 之间协同作用的原理：mP-GEM 预处理能够比单独的 mP-DACH Pt 处理更有效地增强铂-DNA 加合物的积累并抑制细胞增殖。这些观察结果对于基于第二代主链可降解 HPMA 共聚物的卵巢癌联合大分子治疗的开发是有用的。