Bilgir Oktay, Bilgir Ferda, Bozkaya Giray, Calan Mehmet
aDepartment of Hematology, Izmir Bozyaka Training and Research Hospital, Bozyaka, Izmir bDepartment of Allergy and Immunology, Celal Bayar University Medical School, Manisa cDepartment of Biochemistry, Izmir Bozyaka Training and Research Hospital, Bozyaka, Izmir dDepartment of Endocrine and Metabolism, Dokuz Eylul University Medical School, Izmir, Turkey.
Blood Coagul Fibrinolysis. 2014 Mar;25(2):151-5. doi: 10.1097/MBC.0000000000000009.
In a majority of patients with nonalcoholic fatty liver disease (NAFLD), cardiovascular risk factors including diabetes mellitus type 2, abdominal obesity, and metabolic syndrome are present. The purpose of this study is to investigate the presence of endothelial injury and the changes in coagulation parameters in NAFLD patients. For this purpose, plasma levels of von Willebrand factor (vWF), thrombomodulin, urokinase plasminogen activator (uPA), plasminogen activator inhibitor-1 (PAI-1), and tissue factor pathway inhibitor (TFPI) in patients with NAFLD were measured. There was a significant difference in vWF and TFPI levels between patient and control groups (P < 0.05). However, no statistically significant difference was obtained in PAI-1, uPA, and thrombomodulin levels between the two groups (P > 0.05). According to our results, an increase in vWF and TFPI levels indicates an endothelial injury in NAFLD cases.
在大多数非酒精性脂肪性肝病（NAFLD）患者中，存在包括2型糖尿病、腹型肥胖和代谢综合征在内的心血管危险因素。本研究的目的是调查NAFLD患者内皮损伤的存在情况以及凝血参数的变化。为此，测量了NAFLD患者血浆中血管性血友病因子（vWF）、血栓调节蛋白、尿激酶型纤溶酶原激活剂（uPA）、纤溶酶原激活剂抑制剂-1（PAI-1）和组织因子途径抑制剂（TFPI）的水平。患者组和对照组之间的vWF和TFPI水平存在显著差异（P<0.05）。然而，两组之间的PAI-1、uPA和血栓调节蛋白水平没有获得统计学上的显著差异（P>0.05）。根据我们的结果，vWF和TFPI水平的升高表明NAFLD病例存在内皮损伤。
