软珊瑚 Sinularia sp. 中新型倍半萜新化合物

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.

Mar Drugs. 2013 Dec 2;11(12):4741-50. doi: 10.3390/md11124741.

Four new sesquiterpenes, sinularianins C-F (3-6), together with known sinularianins A (1) and B (2) were identified from a South China Sea soft coral Sinularia sp. Compounds 1-6 were evaluated for inhibition of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay. Compounds 1 and 4 were exhibited a potent effect with inhibitory rates of 41.3% and 43.0% at the concentration of 10 µg/mL, respectively.

从南海软珊瑚 Sinularia sp.中分离得到了 4 个新的倍半萜类化合物 sinularianins C-F（3-6），以及已知的 sinularianins A（1）和 B（2）。采用基于细胞的 HEK293 NF-κB 荧光素酶报告基因检测法，评估了化合物 1-6 对 NF-κB 激活的抑制作用。化合物 1 和 4 在 10 µg/mL 浓度下表现出很强的抑制作用，抑制率分别为 41.3%和 43.0%。