Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Chinese Medicinal Research and Development Center, China Medical University and Hospital, Taichung 404, Taiwan.
Mar Drugs. 2011;9(10):1955-1968. doi: 10.3390/md9101955. Epub 2011 Oct 17.
Eight new cembranoids, crassarines A-H (1-8) were isolated from the Formosan soft coral Sinularia crassa. Compounds 1-3 represent the rare cembranoids with a 1,12-oxa-bridged tetrahydrofuran ring, while 4 and 5 are the firstly discovered 1,11-oxa-bridged tetrahydropyranocembranoids. The absolute configuration of 6 was determined using the Mosher's method. Compounds 6 and 8 were found to significantly inhibit the expression of both pro-inflammatory iNOS and COX-2 proteins at 10 μM, respectively, while compounds 4-8 were found to be non-cytotoxic toward the selected human liver cancer cells.
从台湾产软珊瑚 Sinularia crassa 中分离得到了 8 种新的海鞘素类化合物，分别命名为 crassarines A-H（1-8）。化合物 1-3 代表了具有 1,12-氧桥四氢呋喃环的罕见海鞘素类化合物，而 4 和 5 则是首次发现的 1,11-氧桥四氢吡喃海鞘素类化合物。通过 Mosher 法确定了化合物 6 的绝对构型。化合物 6 和 8 在 10 μM 时均显著抑制促炎 iNOS 和 COX-2 蛋白的表达，而化合物 4-8 对所选人肝癌细胞无细胞毒性。
