Wu Huanlei, Hu Jia, Liu Bo, Tao Yu, Zhou Xiao, Yuan Xianglin
Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, Hubei Province, China.
Tumour Biol. 2014 Apr;35(4):3657-62. doi: 10.1007/s13277-013-1484-6. Epub 2013 Dec 7.
Interleukin-4 (IL-4) -524C > T polymorphism has been implicated to alter the risk of colorectal cancer (CRC), but the results are controversial. The objective of this study was to quantitatively evaluate the association between IL-4 -524C > T polymorphism and CRC risk. A comprehensive search was conducted to identify all eligible studies of IL-4 -524C > T polymorphism and CRC risk. Statistical analysis was performed with Review Manager 5.0 and Stata 11. A total of 5 case-control studies, including 1,224 cases and 1,551 controls, were included. The combined results based on all eligible studies suggested that IL-4 -524C > T polymorphism was not associated with CRC susceptibility. When stratifying for race, the data showed that the IL-4 -524C > T polymorphism was also not associated with an increased CRC susceptibility in Caucasians. Our study suggests that IL-4 -524C > T polymorphism may be not associated with an increased CRC susceptibility.
白细胞介素-4（IL-4）-524C>T多态性被认为会改变结直肠癌（CRC）的风险，但结果存在争议。本研究的目的是定量评估IL-4 -524C>T多态性与CRC风险之间的关联。进行了全面检索，以确定所有关于IL-4 -524C>T多态性与CRC风险的符合条件的研究。使用Review Manager 5.0和Stata 11进行统计分析。共纳入5项病例对照研究，包括1224例病例和1551例对照。基于所有符合条件研究的综合结果表明，IL-4 -524C>T多态性与CRC易感性无关。按种族分层时，数据显示IL-4 -524C>T多态性在白种人中也与CRC易感性增加无关。我们的研究表明，IL-4 -524C>T多态性可能与CRC易感性增加无关。
