Harmon Kimberly G, Rao Ashwin L
1Departments of Family Medicine and Orthopaedics and Sports Medicine, University of Washington, Seattle, WA.
Hematology Am Soc Hematol Educ Program. 2013;2013:620-6. doi: 10.1182/asheducation-2013.1.620.
Interest in platelet-rich plasma (PRP) has skyrocketed over the last decade, with a growing body of research contributing to both excitement and skepticism regarding its use. Despite mixed opinions in the medical field, interest from the public has fueled increased utilization of PRP for musculoskeletal conditions, particularly those that are difficult to treat such as chronic, degenerative tendinopathy and osteoarthritis. PRP's reputation as a "natural healer" and stories in the lay press featuring the use of PRP by professional athletes and celebrities has created a lucrative market for PRP even absent insurance reimbursement, casting further doubt regarding motivation for use by some practitioners. Research of PRP is clouded by the fact that PRP is a heterogeneous term representing a variety of different platelet preparations and there are many variables in technique and postprocedure rehabilitation, all of which may have significant effects on outcome. This article discusses definitions and classification of PRP, reviews rationale and evidence for use of PRP in chronic tendon injuries and osteoarthritis, and looks at future directions.
在过去十年中，对富含血小板血浆（PRP）的兴趣急剧上升，越来越多的研究引发了人们对其应用既兴奋又怀疑的态度。尽管医学领域存在不同意见，但公众的兴趣推动了PRP在肌肉骨骼疾病中的使用增加，尤其是那些难以治疗的疾病，如慢性、退行性肌腱病和骨关节炎。PRP作为“天然治愈者”的声誉以及大众媒体上关于职业运动员和名人使用PRP的报道，即使在没有保险报销的情况下，也为PRP创造了一个利润丰厚的市场，这进一步引发了人们对一些从业者使用动机的质疑。由于PRP是一个异质术语，代表各种不同的血小板制剂，并且在技术和术后康复方面存在许多变量，所有这些都可能对结果产生重大影响，因此对PRP的研究也受到了影响。本文讨论了PRP的定义和分类，回顾了PRP在慢性肌腱损伤和骨关节炎中应用的理论依据和证据，并展望了未来的发展方向。
