Zheng Zefeng, Le Huihui, Chen Weishan, Shen Weiliang, Ouyang Hongwei
Center of Stem Cell and Tissue Engineering, Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Key Laboratory of Stem Cell of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China; Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Hangzhou 310009, China.
Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Hangzhou 310009, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2016 Mar;45(2):179-86. doi: 10.3785/j.issn.1008-9292.2016.03.11.
Platelet-enriched plasma (PRP) contains high concentration of platelets and abundant growth factors, which is made by centrifuging of blood and separating of blood elements. PRP promotes tendon repair by releasing various cytokines to enhance cell proliferation, tenogenic differentiation, formation and secretion of matrix; meantime, it can reduce pain by inhibiting the expression of pain-associated molecules. A number of clinical studies demonstrated that PRP was effective in treatment of tendinopathy, including patellar tendinopathy, lateral epicondylitis and plantar fasciopathy. However, some studies did not support this conclusion, because of disparity of PRP types, therapeutic courses and injections protocols in clinical application. Based on its safety, PRP can be a choice of treatment for tendinopathy, in case other non-surgical therapies are of no effect.
富血小板血浆（PRP）含有高浓度的血小板和丰富的生长因子，它是通过血液离心和血细胞分离制成的。PRP通过释放各种细胞因子促进肌腱修复，以增强细胞增殖、腱性分化、基质的形成和分泌；同时，它可以通过抑制疼痛相关分子的表达来减轻疼痛。多项临床研究表明，PRP在治疗肌腱病方面是有效的，包括髌腱炎、外侧上髁炎和足底筋膜炎。然而，一些研究并不支持这一结论，因为临床应用中PRP的类型、治疗疗程和注射方案存在差异。基于其安全性，在其他非手术治疗无效的情况下，PRP可以作为肌腱病的一种治疗选择。
