Department of Ophthalmology, Hospital Clinico Universitario Lozano Blesa, Aragon Health Sciences Institute, 50009 Zaragoza, Spain.
Biomed Res Int. 2013;2013:341269. doi: 10.1155/2013/341269. Epub 2013 Nov 11.
To evaluate the ability of frequency-doubling technology (FDT) perimetry in detecting visual field defects in young adults with type I diabetes prior to retinopathy or with minor retinovascular changes.
This comparative cross-sectional study included 30 healthy subjects and 73 age-matched patients with type I diabetes mellitus. All subjects underwent a full ocular examination including an FDT with the threshold C-20-5 strategy. Only one eye per subject was randomly included in the statistical analysis. FDT results and time to perform the test were compared between the groups.
The mean age was 27.1 years in the control group and 26.6 years in the diabetic group (P = 0.875). The mean period from the onset of diabetes was 12.6 ± 6.7 years, while minimal retinovascular changes were observed in 18 eyes. Mean deviation of FDT did not differ between the groups. Although global indices of FDT were within normal limits, pattern standard deviation of FDT was higher in the diabetic group (P = 0.035). The area under the receiver operating characteristic curve was 0.647 for pattern standard deviation of FDT (standard error = 0.052; P = 0.017).
FDT can detect retinal dysfunctions in diabetic patients prior to the onset of significant vascular complications.
评估倍频技术（FDT）在糖尿病 I 型患者发生视网膜病变或轻微血管改变之前检测其视野缺陷的能力。
本研究为前瞻性对比研究，纳入 30 名健康受试者和 73 名年龄匹配的 I 型糖尿病患者。所有患者均接受全面眼科检查，包括使用阈值 C-20-5 策略进行 FDT。每位患者仅随机纳入一只眼进行统计分析。比较两组间 FDT 结果和检测时间。
对照组的平均年龄为 27.1 岁，糖尿病组为 26.6 岁（P=0.875）。糖尿病发病至检查的平均时间为 12.6±6.7 年，其中 18 只眼观察到最小程度的血管改变。FDT 平均偏差在两组间无差异。尽管 FDT 的全局指数在正常范围内，但糖尿病组的 FDT 模式标准差较高（P=0.035）。FDT 模式标准差的受试者工作特征曲线下面积为 0.647（标准误差=0.052；P=0.017）。
FDT 可在糖尿病患者出现显著血管并发症之前检测视网膜功能障碍。
