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抗绵羊淋巴细胞单克隆抗体。I. 淋巴组织上MHC II类分子的鉴定以及体内抗原刺激后淋巴源性细胞上II类分子表达水平的变化。

Monoclonal antibodies to sheep lymphocytes. I. Identification of MHC class II molecules on lymphoid tissue and changes in the level of class II expression on lymph-borne cells following antigen stimulation in vivo.

作者信息

Hopkins J, Dutia B M, McConnell I

出版信息

Immunology. 1986 Nov;59(3):433-8.

PMID:2431999
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1453204/
Abstract

A rat monoclonal antibody is described that recognizes sheep MHC Class II antigen and appears to recognize a determinant that is non-polymorphic. This antibody precipitates polypeptides of apparent molecular weight 33,000 and 28,000/29,000 (under non-reducing conditions). The binding of this antibody was inhibited by an anti-human DP, DQ, DR beta-chain monoclonal (DA6.231) and its reactivity on murine cells suggests specificity for the I-E gene product. Using this antibody we have studied the distribution of Class II molecules in sheep and also the variations in Class II expression by cells in both peripheral and efferent lymph, produced as a result of in vivo antigen inoculation.

摘要

描述了一种大鼠单克隆抗体，它可识别绵羊MHC II类抗原，且似乎识别一种非多态性的决定簇。该抗体在非还原条件下沉淀出表观分子量为33,000和28,000/29,000的多肽。这种抗体的结合被抗人DP、DQ、DRβ链单克隆抗体（DA6.231）抑制，其在鼠细胞上的反应性表明对I-E基因产物具有特异性。利用该抗体，我们研究了绵羊中II类分子的分布，以及体内接种抗原后外周淋巴和输出淋巴中细胞II类表达的变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/396d/1453204/0b4308aa0a4a/immunology00176-0101-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/396d/1453204/0b4308aa0a4a/immunology00176-0101-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/396d/1453204/0b4308aa0a4a/immunology00176-0101-a.jpg

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