Abate Nicola, Sallam Hanaa S, Rizzo Manfredi, Nikolic Dragana, Obradovic Milan, Bjelogrlic Predrag, Isenovic Esma R
Institute Vinca, University of Belgrade, Laboratory of Radiobiology and Molecular Genetics, P.O.Box 522, 11000 Belgrade, Serbia.
Curr Pharm Des. 2014;20(31):4961-9. doi: 10.2174/1381612819666131206103102.
Resistin is an adipocyte- and monocyte-derived cytokine which has been implicated in the modulation of insulin action, energy, glucose and lipid homeostasis. Resistin has been associated with insulin resistance and many of its known complications. As a molecular link between metabolic signals, inflammation, and vascular dysfunction, resistin can be proposed as playing a significant role in the heightened inflammatory state induced by metabolic stress linked to excessive caloric intake, thus contributing to the risk for metabolic syndrome (MetS), type 2 diabetes (T2DM), and cardiovascular diseases (CVD). In this review, we highlighted the role of resistin, as an inflammatory cytokine, in the development of CVD, T2DM and the MetS.
抵抗素是一种由脂肪细胞和单核细胞产生的细胞因子，与胰岛素作用、能量、葡萄糖和脂质稳态的调节有关。抵抗素与胰岛素抵抗及其许多已知并发症相关。作为代谢信号、炎症和血管功能障碍之间的分子联系，抵抗素在由与热量摄入过多相关的代谢应激诱导的炎症状态升高中可能发挥重要作用，从而增加代谢综合征（MetS）、2型糖尿病（T2DM）和心血管疾病（CVD）的风险。在本综述中，我们强调了抵抗素作为一种炎症细胞因子在CVD、T2DM和MetS发生发展中的作用。
