Marklund S L, Kling P A, Nilsson S, Ohman M
Department of Clinical Chemistry, Umeå University Hospital, Sweden.
Scand J Clin Lab Invest. 1987 Oct;47(6):567-70. doi: 10.1080/00365518709168470.
Trauma, inflammatory disorders and other perturbations induce the so-called acute phase response in organisms. The phenomenon encompasses many physiological alterations including typical changes in plasma proteins. Often an accumulation and activation of superoxide radical-producing leucocytes occurs at the site of perturbation. The major enzymic protector against superoxide radicals in plasma and other extracellular fluids is extracellular-superoxide dismutase. The acute phase response of extracellular-superoxide dismutase was investigated in two groups, one comprising 13 patients in the postoperative period after surgical trauma and the other 15 patients with various inflammatory disorders. No significant positive or negative acute phase response of plasma extracellular-superoxide dismutase was revealed.
创伤、炎症性疾病和其他干扰因素会在生物体中引发所谓的急性期反应。这一现象包括许多生理变化，其中就有血浆蛋白的典型变化。在干扰部位常常会出现产生超氧自由基的白细胞的聚集和激活。血浆和其他细胞外液中对抗超氧自由基的主要酶性保护剂是细胞外超氧化物歧化酶。在两组患者中研究了细胞外超氧化物歧化酶的急性期反应，一组包括13例手术创伤术后患者，另一组包括15例患有各种炎症性疾病的患者。未发现血浆细胞外超氧化物歧化酶有显著的阳性或阴性急性期反应。
