Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61821, USA.
Lab Chip. 2014 Feb 21;14(4):646-52. doi: 10.1039/c3lc51033f.
Characterizing the physical properties of single cells is of great interest for unraveling the heterogeneity in a cell population. Recent advances in micro-systems technologies and quantitative imaging have enabled measurements of the mass and growth of single cells. So far, three classes of techniques have been reported for such measurements. These are suspended micro-channel resonators (SMR) sensors, quantitative phase imaging (QPI), and pedestal resonant sensors. Here we compare the unique merits of each method and discuss their potential to evolve into multi-modal platforms for answering fundamental questions in biology and medicine.
研究单个细胞的物理特性对于揭示细胞群体的异质性具有重要意义。微系统技术和定量成像技术的最新进展使得对单个细胞的质量和生长的测量成为可能。到目前为止，已经报道了三类用于此类测量的技术。这些技术分别是悬浮微通道谐振器 (SMR) 传感器、定量相位成像 (QPI) 和基座谐振传感器。在这里，我们比较了每种方法的独特优点，并讨论了它们演变成用于回答生物学和医学基本问题的多模态平台的潜力。
