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In vitro activity of fosfomycin against a collection of clinical Pseudomonas aeruginosa isolates from 16 Spanish hospitals: establishing the validity of standard broth microdilution as susceptibility testing method.体外研究磷霉素对来自 16 家西班牙医院的临床铜绿假单胞菌分离株的活性：确证标准肉汤微量稀释法作为药敏试验方法的有效性。
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Experience with fosfomycin for treatment of urinary tract infections due to multidrug-resistant organisms.磷霉素治疗多重耐药菌引起的尿路感染的经验。
Antimicrob Agents Chemother. 2012 Nov;56(11):5744-8. doi: 10.1128/AAC.00402-12. Epub 2012 Aug 27.
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Tigecycline and intravenous fosfomycin zone breakpoints equivalent to the EUCAST MIC criteria for Enterobacteriaceae.替加环素和静脉注射磷霉素的抑菌圈直径断点等同于针对肠杆菌科细菌的欧洲抗菌药物敏感性试验委员会（EUCAST）最低抑菌浓度（MIC）标准。
J Infect Dev Ctries. 2012 May 14;6(5):452-6. doi: 10.3855/jidc.2238.
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Essentials for selecting antimicrobial therapy for intra-abdominal infections.腹腔内感染抗菌治疗的选择要点。
Drugs. 2012 Apr 16;72(6):e17-32. doi: 10.2165/11599800-000000000-00000.
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High prevalence of OXA-143 and alteration of outer membrane proteins in carbapenem-resistant Acinetobacter spp. isolates in Brazil.巴西耐碳青霉烯类不动杆菌属分离株中 OXA-143 的高流行率和外膜蛋白的改变。
Int J Antimicrob Agents. 2012 May;39(5):396-401. doi: 10.1016/j.ijantimicag.2012.01.021. Epub 2012 Mar 26.
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Mechanisms of resistance and clinical relevance of resistance to β-lactams, glycopeptides, and fluoroquinolones.β-内酰胺类、糖肽类和氟喹诺酮类耐药的机制及其临床相关性。
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Fosfomycin: evaluation of the published evidence on the emergence of antimicrobial resistance in Gram-negative pathogens.磷霉素：对革兰氏阴性病原体出现抗微生物耐药性的已发表证据的评估。
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Antimicrobials in urogenital infections.泌尿生殖系统感染中的抗菌药物。
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The revival of fosfomycin.磷霉素的复兴。
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Spread of carbapenem-resistant Klebsiella pneumoniae in a tertiary hospital in Sao Paulo, Brazil.耐碳青霉烯类肺炎克雷伯菌在巴西圣保罗一家三级医院的传播情况。
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多重耐药革兰氏阴性菌对磷霉素的敏感性及不同药敏试验方法的性能

Susceptibility of multiresistant gram-negative bacteria to fosfomycin and performance of different susceptibility testing methods.

作者信息

Perdigão-Neto L V, Oliveira M S, Rizek C F, Carrilho C M D M, Costa S F, Levin A S

机构信息

Department of Infection Control of Hospital das Clínicas, University of São Paulo, São Paulo, Brazil.

出版信息

Antimicrob Agents Chemother. 2014;58(3):1763-7. doi: 10.1128/AAC.02048-13. Epub 2013 Dec 9.

DOI:10.1128/AAC.02048-13
PMID:24323469
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3957874/
Abstract

Fosfomycin may be a treatment option for multiresistant Gram-negative bacteria. This study compared susceptibility methods using 94 multiresistant clinical isolates. With agar dilution (AD), susceptibilities were 81%, 7%, 96%, and 100% (CLSI) and 0%, 0%, 96%, and 30% (EUCAST), respectively, for Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Enterobacter spp. Categorical agreement between Etest and AD for Enterobacteriaceae and A. baumannii was ≥80%. Disk diffusion was adequate only for Enterobacter. CLSI criteria for urine may be adequate for systemic infections.

摘要

磷霉素可能是治疗多重耐药革兰氏阴性菌的一种选择。本研究使用94株多重耐药临床分离株比较了药敏试验方法。对于鲍曼不动杆菌、铜绿假单胞菌、肺炎克雷伯菌和肠杆菌属，采用琼脂稀释法（AD）时，根据美国临床和实验室标准协会（CLSI）标准的药敏率分别为81%、7%、96%和100%，而根据欧洲抗菌药物敏感性试验委员会（EUCAST）标准的药敏率分别为0%、0%、96%和30%。对于肠杆菌科细菌和鲍曼不动杆菌，Etest法与AD法的分类一致性≥80%。纸片扩散法仅对肠杆菌适用。CLSI的尿液标准可能适用于全身性感染。