鳞状细胞癌中的一个外来者！
A foreigner in squamous cell carcinoma!
作者信息
Patil Shankargouda, Rao Roopa S, Ganavi B S
机构信息
Department of Oral & Maxillofacial Pathology, M S Ramaiah Dental College & Hospital, Bangalore, Karnataka, India.
出版信息
J Int Oral Health. 2013 Oct;5(5):147-50. Epub 2013 Oct 26.
Giant cells are the soldiers of defensive system of our body. They differ based on the stimuli that provoked their formation. On the other hand, squamous cell carcinoma (SCC) being the most common oral cancer, presents with varied histopathological features based on the degree of differentiation. Keratinizing islands of dysplastic squamous epithelial cells & a dense inflammatory response form the major component of well differentiated SCC. This keratin component may sometimes trigger foreign body giant cell (FBGC) reaction in the stroma, which may mislead the pathologist to aggressive forms of SCC containing pleomorphic giant cells. We encountered such an interesting case of foreign body giant cell reaction in oral SCC. Thus, the present article aims to provide a thorough knowledge on FBGC including their appearance, pathogenesis & significance in oral SCC. How to cite this article: Patil S, Rao RS, Ganavi BS. A Foreigner in Squamous Cell Carcinoma!. J Int Oral Health 2013;5(5):147-50.
巨细胞是我们身体防御系统的“战士”。它们因引发其形成的刺激因素不同而有所差异。另一方面，鳞状细胞癌（SCC）是最常见的口腔癌，根据分化程度呈现出不同的组织病理学特征。发育异常的鳞状上皮细胞的角化岛和密集的炎症反应构成了高分化SCC的主要成分。这种角蛋白成分有时可能会在基质中引发异物巨细胞（FBGC）反应，这可能会误导病理学家将其误诊为含有多形性巨细胞的侵袭性SCC形式。我们遇到了这样一例口腔SCC中异物巨细胞反应的有趣病例。因此，本文旨在全面介绍FBGC，包括它们在口腔SCC中的外观、发病机制及意义。如何引用本文：帕蒂尔S，拉奥RS，加纳维BS。鳞状细胞癌中的“外来者”！《国际口腔健康杂志》2013年；5（5）：147 - 50。
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