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介孔硅微粒增强人树突状细胞的MHC I类交叉抗原呈递。

Mesoporous silicon microparticles enhance MHC class I cross-antigen presentation by human dendritic cells.

作者信息

Jiménez-Periáñez A, Abos Gracia B, López Relaño J, Diez-Rivero C M, Reche P A, Martínez-Naves E, Matveyeva E, Gómez del Moral M

机构信息

EM-Silicon Nano-Technologies SL, Nat. R. Cisternas 8, 46010 Valencia, Spain.

出版信息

Clin Dev Immunol. 2013;2013:362163. doi: 10.1155/2013/362163. Epub 2013 Nov 10.

DOI:10.1155/2013/362163
PMID:24324504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3842076/
Abstract

The mesoporous silicon microparticles (MSMPs) are excellent vehicles for releasing molecules inside the cell. The aim of this work was to use MSMPs to deliver viral specific MHC class I restricted epitopes into human antigen presenting cells (monocyte derived dendritic cells, MDDCs) to facilitate their capture, processing, and presentation to CD8+ (cytotoxic) T lymphocytes. We show for the first time that MSMPs vehiculation of antigenic peptides enhances their MHC class I presentation by human MDDCs to CD8 T lymphocytes.

摘要

介孔硅微粒（MSMPs）是在细胞内释放分子的优良载体。本研究的目的是利用MSMPs将病毒特异性MHC I类限制性表位递送至人抗原呈递细胞（单核细胞衍生树突状细胞，MDDCs），以促进其捕获、加工并呈递给CD8+（细胞毒性）T淋巴细胞。我们首次表明，MSMPs运载抗原肽可增强人MDDCs将其MHC I类呈递给CD8 T淋巴细胞的能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bc3/3842076/158deb1ccafc/CDI2013-362163.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bc3/3842076/5507aff6babb/CDI2013-362163.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bc3/3842076/0fbfd1e3b00e/CDI2013-362163.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bc3/3842076/bccf4c5bc2e1/CDI2013-362163.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bc3/3842076/dd0dbdcbd570/CDI2013-362163.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bc3/3842076/158deb1ccafc/CDI2013-362163.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bc3/3842076/5507aff6babb/CDI2013-362163.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bc3/3842076/0fbfd1e3b00e/CDI2013-362163.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bc3/3842076/bccf4c5bc2e1/CDI2013-362163.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bc3/3842076/dd0dbdcbd570/CDI2013-362163.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bc3/3842076/158deb1ccafc/CDI2013-362163.005.jpg

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