长期膳食钠、钾和液体摄入；探索荷兰饮食与癌症队列研究中肾癌的潜在新危险因素。
Long-term dietary sodium, potassium and fluid intake; exploring potential novel risk factors for renal cell cancer in the Netherlands Cohort Study on diet and cancer.
机构信息
Department of Epidemiology, School for Oncology and Developmental Biology (GROW), Maastricht University Medical Centre, Peter Debyeplein 1, Maastricht 6229 HA, The Netherlands.
Department of Pathology, School for Oncology and Developmental Biology (GROW), Maastricht University Medical Centre, Peter Debyelaan 25, Maastricht 6229 HX, The Netherlands.
出版信息
Br J Cancer. 2014 Feb 4;110(3):797-801. doi: 10.1038/bjc.2013.771. Epub 2013 Dec 10.
Abstract
BACKGROUND
As sodium, potassium and fluid intake are related to hypertension, an established risk factor for renal cell cancer (RCC), they may be independent risk factors for RCC.
METHODS
The Netherlands Cohort Study (NLCS) with case-cohort design included 120,852 participants aged 55-69 years. At baseline, diet and lifestyle were assessed with questionnaires. After 17.3 years of follow-up, 485 RCC cases and 4438 subcohort members were available for analyses.
RESULTS
Sodium intake increased RCC risk (P-trend=0.03), whereas fluid and potassium intake did not. For high sodium and low fluid intake, the RCC risk additionally increased (P-interaction=0.02).
CONCLUSION
Sodium intake is a potential risk factor for RCC, particularly if fluid consumption is low.
摘要
背景
钠、钾和液体摄入量与高血压有关，高血压是肾细胞癌（RCC）的一个既定风险因素，因此它们可能是 RCC 的独立风险因素。
方法
采用病例-队列设计的荷兰队列研究（NLCS）纳入了 120852 名年龄在 55-69 岁的参与者。在基线时，通过问卷评估饮食和生活方式。随访 17.3 年后，有 485 例 RCC 病例和 4438 名亚队列成员可用于分析。
结果
钠摄入量增加了 RCC 风险（P 趋势=0.03），而液体和钾摄入量没有。对于高钠和低液体摄入，RCC 风险进一步增加（P 交互=0.02）。
结论
钠摄入量是 RCC 的一个潜在风险因素，特别是如果液体摄入较低。
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本文引用的文献
1
Salt in health and disease--a delicate balance.健康与疾病中的盐分——微妙的平衡。
N Engl J Med. 2013 Mar 28;368(13):1229-37. doi: 10.1056/NEJMra1212606.
2
Salt consumption and cardiovascular, renal, and hypertensive diseases: clinical and mechanistic aspects.盐的摄入与心血管、肾脏和高血压疾病：临床和机制方面。
Curr Opin Lipidol. 2012 Feb;23(1):11-6. doi: 10.1097/MOL.0b013e32834d9c52.
3
Statins reverse renal inflammation and endothelial dysfunction induced by chronic high salt intake.他汀类药物可逆转慢性高盐摄入引起的肾脏炎症和内皮功能障碍。
Am J Physiol Renal Physiol. 2011 Aug;301(2):F263-70. doi: 10.1152/ajprenal.00109.2010. Epub 2011 May 4.
4
Fluid intake and incidence of renal cell carcinoma in UK women.液体摄入量与英国女性肾癌发病风险的关系
Br J Cancer. 2011 Apr 26;104(9):1487-92. doi: 10.1038/bjc.2011.90. Epub 2011 Mar 15.
5
Hallmarks of cancer: the next generation.癌症的特征：下一代。
Cell. 2011 Mar 4;144(5):646-74. doi: 10.1016/j.cell.2011.02.013.
6
Epidemiology and risk factors for kidney cancer.肾癌的流行病学和危险因素。
Nat Rev Urol. 2010 May;7(5):245-57. doi: 10.1038/nrurol.2010.46.
7
Total fluid and specific beverage intake and risk of renal cell carcinoma in Canada.加拿大总液体和特定饮料摄入与肾细胞癌风险的关系。
Cancer Epidemiol. 2009 Nov;33(5):355-62. doi: 10.1016/j.canep.2009.10.004. Epub 2009 Nov 7.
8
Total fluid intake and use of individual beverages and risk of renal cell cancer in two large cohorts.两个大型队列中总液体摄入量、个体饮料的饮用情况与肾细胞癌风险
Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1204-11. doi: 10.1158/1055-9965.EPI-05-0889.
9
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10
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Cancer Causes Control. 2003 Jun;14(5):427-38. doi: 10.1023/a:1024979314124.
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