Kwong Lawrence N, Heffernan Timothy P, Chin Lynda
1Department of Genomic Medicine and 2Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Cancer Discov. 2013 Dec;3(12):1339-44. doi: 10.1158/2159-8290.CD-13-0394.
The identification of evidence-based, efficacious drug combinations for each cancer, among thousands of potential permutations, is a daunting task. In this perspective, we propose a systematic approach to defining such combinations by molecularly benchmarking a drug against a desired state of efficacy using model systems.
在数千种可能的组合中，为每种癌症确定基于证据的有效药物组合是一项艰巨的任务。从这个角度来看，我们提出了一种系统的方法，通过使用模型系统将一种药物与期望的疗效状态进行分子层面的对比，来定义此类组合。
