简明综述：角膜缘干细胞的鉴定：经典概念与新挑战。
Concise review: identifying limbal stem cells: classical concepts and new challenges.
机构信息
Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
出版信息
Stem Cells Transl Med. 2014 Mar;3(3):318-22. doi: 10.5966/sctm.2013-0137. Epub 2013 Dec 10.
Abstract
The presence of a clear cornea is required for vision, and corneal epithelial cells play a key role. There is a long held view, supported by decades of study, that corneal epithelial stem cells reside at the limbus to regulate homeostatic cell turnover and wound healing. However, the identification of specific markers that allow the isolation and characterization of limbal stem cells remains elusive. Here, we review the classical concepts of limbal stem cell identity and highlight the current state of the field.
摘要
清晰的角膜是视力所必需的，而角膜上皮细胞起着关键作用。长期以来，人们一直认为角膜上皮干细胞位于角膜缘，以调节细胞的稳态更新和伤口愈合。然而，能够分离和鉴定角膜缘干细胞的特异性标志物仍然难以确定。在这里，我们回顾了角膜缘干细胞特性的经典概念，并强调了该领域的现状。
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