O'Dorisio M S
Am J Med. 1986 Dec 22;81(6B):74-82. doi: 10.1016/0002-9343(86)90587-5.
Several peptides originally described as neurotransmitters or gut hormones have recently been shown to modulate the immune response. Three of these peptides, vasoactive intestinal peptide, substance P, and somatostatin, regulate the function of immune effector cells in gut-associated lymphoid tissue. Vasoactive intestinal peptide modulates lymphocyte migration and natural killer cell activity by a cyclic adenosine monophosphate (cAMP)-dependent mechanism, whereas substance P induces mediator release by a cAMP-independent mechanism. Somatostatin antagonizes the effects of both vasoactive intestinal peptide and substance P by a mechanism that appears to involve inhibitory guanine nucleotide binding proteins. Neuropeptide regulation of immune cells in gut-associated lymphoid tissue may thus play an important role in gastrointestinal physiology.
最初被描述为神经递质或胃肠激素的几种肽，最近已被证明可调节免疫反应。其中三种肽，即血管活性肠肽、P物质和生长抑素，调节肠道相关淋巴组织中免疫效应细胞的功能。血管活性肠肽通过依赖环磷酸腺苷（cAMP）的机制调节淋巴细胞迁移和自然杀伤细胞活性，而P物质通过不依赖cAMP的机制诱导介质释放。生长抑素通过一种似乎涉及抑制性鸟嘌呤核苷酸结合蛋白的机制拮抗血管活性肠肽和P物质的作用。因此，肠道相关淋巴组织中免疫细胞的神经肽调节可能在胃肠生理学中起重要作用。
