线粒体融合与裂变蛋白：对抗心血管疾病的新型治疗靶点。
Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease.
作者信息
Hall A R, Burke N, Dongworth R K, Hausenloy D J
机构信息
The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, NIHR University College London Hospitals Biomedical Research Centre, University College London Hospital & Medical School, London, UK.
出版信息
Br J Pharmacol. 2014 Apr;171(8):1890-906. doi: 10.1111/bph.12516.
Mitochondria are no longer considered to be solely the static powerhouses of the cell. While they are undoubtedly essential to sustaining life and meeting the energy requirements of the cell through oxidative phosphorylation, they are now regarded as highly dynamic organelles with multiple functions, playing key roles in cell survival and death. In this review, we discuss the emerging role of mitochondrial fusion and fission proteins, as novel therapeutic targets for treating a wide range of cardiovascular diseases.
线粒体不再被认为仅仅是细胞的静态动力源。虽然它们无疑对于维持生命以及通过氧化磷酸化满足细胞的能量需求至关重要，但现在它们被视为具有多种功能的高度动态的细胞器，在细胞存活和死亡中发挥关键作用。在本综述中，我们讨论线粒体融合和裂变蛋白的新作用，作为治疗多种心血管疾病的新型治疗靶点。
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