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皮下避孕埋植剂依伴侬(Implanon®)的续用率及相关影响因素

Continuation rates of the subdermal contraceptive Implanon(®) and associated influencing factors.

作者信息

Teunissen Anna Maria, Grimm Bernd, Roumen Frans J M E

机构信息

* Maastricht University, Faculty of Health, Medicine and Life Sciences , Maastricht , the Netherlands.

出版信息

Eur J Contracept Reprod Health Care. 2014 Feb;19(1):15-21. doi: 10.3109/13625187.2013.862231. Epub 2013 Dec 13.

Abstract

OBJECTIVES To investigate the continuation rates of the etonogestrel subdermal contraceptive implant among well-informed women, and the reasons for early discontinuation. STUDY DESIGN Retrospective consecutive cohort design. METHODS Women who had the implant inserted between 1 January 2006 and 1 January 2010 at the Atrium Medical Centre, the Netherlands were followed up for at least three years. The dates of insertion and removal were recorded, as were the reasons for removal. Statistical analysis was performed using the independent samples t-test and the Pearson alpha correlation test. RESULTS The implant was inserted in 230 women. Follow-up was possible in 214 women, with an average age of 26.7 years. Most of them were nulliparous and the majority had used a combined oral contraceptive, Implanon®, or Mirena® previously. The mean overall continuation period was 23.5 months (95% confidence interval: 21.7-25.3), with a median of 25 months. The continuation rate after 12 months was 72%; after 24 months, 53%; and after 36 months, 25%, with all women concerned having a new implant placed. The previously used contraceptive method Implanon® was associated with the highest continuation rates. An erratic bleeding pattern was the main reason for early removal. CONCLUSIONS Despite adequate counselling before insertion, the continuation rate of the etonogestrel implant was rather low compared to those reported by other investigators. The main reason for discontinuation was an irregular bleeding pattern.

摘要

目的

调查充分知情的女性中依托孕烯皮下避孕植入剂的续用率,以及早期停用的原因。

研究设计

回顾性连续队列设计。

方法

对2006年1月1日至2010年1月1日期间在荷兰中庭医疗中心植入该植入剂的女性进行至少三年的随访。记录植入和取出的日期以及取出原因。使用独立样本t检验和Pearsonα相关检验进行统计分析。

结果

230名女性植入了该植入剂。214名女性可进行随访,平均年龄为26.7岁。她们大多未生育,多数人之前使用过复方口服避孕药、依伴侬(Implanon®)或曼月乐(Mirena®)。总体平均续用期为23.5个月(95%置信区间:21.7 - 25.3),中位数为25个月。12个月后的续用率为72%;24个月后为53%;36个月后为25%,所有相关女性均植入了新的植入剂。之前使用的避孕方法依伴侬的续用率最高。不规则出血模式是早期取出的主要原因。

结论

尽管在植入前进行了充分的咨询,但与其他研究者报告的相比,依托孕烯植入剂的续用率相当低。停用的主要原因是出血模式不规则。

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