Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
Department of Pulmonary Diseases, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, PR China.
Arch Med Res. 2014 Jan;45(1):21-30. doi: 10.1016/j.arcmed.2013.12.001. Epub 2013 Dec 11.
Mounting data have emerged suggesting that the Connexin37 C1019T polymorphism increases susceptibility to coronary artery disease (CAD). However, previous studies yielded conflicting results. In the current study, a comprehensive meta-analysis was performed to investigate whether the C1019T polymorphism is associated with CAD risk.
A total of 11 studies examining the C1019T polymorphism and CAD were identified using MEDLINE, Embase, CNKI, Wanfang and CBM, in which 5535 CAD patients and 5626 controls were analyzed. A random-effects model was used to calculate odd ratios and confidence intervals, while addressing between-study heterogeneity. Publication bias was weighed using the Egger's test, Begg-Mazemdar test and funnel plot.
In genetic models with striking heterogeneity, the risk of CAD was not associated with the C1019T polymorphism (allele comparison: p = 0.34, OR = 1.11, 95% CI 0.90-1.36). Stratification by disease endpoints indicated that the 1019T allele was significantly associated with myocardial infarction (MI) (allele comparison: p <0.001, OR = 1.59, 95% CI 1.24-2.03). Further meta-regression analysis indicated that a large proportion of heterogeneity was probably due to the varying proportions of diabetes mellitus (DM) across studies (p = 0.014).
Our results indicated that the C1019T polymorphism may be a moderate risk factor for MI and that DM was likely a potential source of between-study heterogeneity.
越来越多的数据表明 Connexin37 C1019T 多态性增加了冠心病（CAD）的易感性。然而，先前的研究结果存在矛盾。本研究采用荟萃分析方法，旨在探讨 C1019T 多态性与 CAD 风险之间的关系。
通过 MEDLINE、Embase、CNKI、万方和 CBM 数据库检索了 11 项关于 C1019T 多态性与 CAD 关系的研究，共纳入 5535 例 CAD 患者和 5626 例对照。采用随机效应模型计算比值比和置信区间，并评估异质性。采用 Egger 检验、Begg-Mazemdar 检验和漏斗图评估发表偏倚。
在具有显著异质性的遗传模型中，CAD 的发病风险与 C1019T 多态性无关（等位基因比较：p = 0.34，OR = 1.11，95%CI 0.90-1.36）。按疾病终点分层表明，1019T 等位基因与心肌梗死（MI）显著相关（等位基因比较：p<0.001，OR = 1.59，95%CI 1.24-2.03）。进一步的荟萃回归分析表明，异质性的很大一部分可能归因于研究间糖尿病（DM）比例的差异（p = 0.014）。
本研究结果表明，C1019T 多态性可能是 MI 的中度危险因素，DM 可能是异质性的潜在来源。
