Li Yan-Yan, Qian Yun, Zhou Chuan-Wei
Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
Biomed Rep. 2013 May;1(3):464-468. doi: 10.3892/br.2013.90. Epub 2013 Mar 27.
The () C1019T gene polymorphism has been suggested to be correlated with increased coronary artery disease (CAD) risk, but research results remain inconsistent. To explore the relationship between the C1019T gene polymorphism and CAD in a Chinese population, the current meta-analysis of 6 individual studies involving 1,244 CAD patients and 962 controls was conducted. The pooled odds ratios (ORs) as well as the corresponding 95% confidence intervals (CIs) were estimated using a random- or fixed-effect model. No significant association was found between C1019T gene polymorphism and CAD in the Chinese population under the allelic (OR=0.96; 95% CI=0.59-1.56, P=0.87), recessive (OR=0.77, 95% CI=0.28-2.08, P=0.60), dominant (OR=0.990, 95% CI=0.773-1.266, P=0.934), additive (OR=1.000, 95% CI=0.736-1.359, P=1.000), homozygous (OR=1.062, 95% CI=0.598-1.887, P=0.836) or heterozygous (OR=1.017, 95% CI=0.802-1.291, P=0.888) genetic models. C1019T gene polymorphism was not suggested to be associated with CAD susceptibility in the Chinese population. In conclusion, no association was found between C1019T gene polymorphism and CAD in the Chinese population.
已有研究表明，（）C1019T基因多态性与冠状动脉疾病（CAD）风险增加相关，但研究结果仍不一致。为探讨中国人群中C1019T基因多态性与CAD的关系，本研究对6项涉及1244例CAD患者和962例对照的个体研究进行了荟萃分析。采用随机或固定效应模型估计合并比值比（OR）及相应的95%置信区间（CI）。在中国人群中，在等位基因（OR=0.96；95%CI=0.59-1.56，P=0.87）、隐性（OR=0.77，95%CI=0.28-2.08，P=0.60）、显性（OR=0.990，95%CI=0.773-1.266，P=0.934）、加性（OR=1.000，95%CI=0.736-1.359，P=1.000）、纯合子（OR=1.062，95%CI=0.598-1.887，P=0.836）或杂合子（OR=1.017，95%CI=0.802-1.291，P=0.888）遗传模型下，未发现C1019T基因多态性与CAD之间存在显著关联。在中国人群中，未提示C1019T基因多态性与CAD易感性相关。总之，在中国人群中未发现C1019T基因多态性与CAD之间存在关联。
