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Common cell biologic and biochemical changes in aging and age-related diseases of the eye: toward new therapeutic approaches to age-related ocular diseases.

作者信息

Whitcomb Elizabeth A, Shang Fu, Taylor Allen

机构信息

Laboratory for Nutrition and Vision Research, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts.

出版信息

Invest Ophthalmol Vis Sci. 2013 Dec 13;54(14):ORSF31-6. doi: 10.1167/iovs.13-12808.

DOI:10.1167/iovs.13-12808
PMID:24335065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3864376/
Abstract
摘要

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A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration.通过限制热量摄入或药物激活 SIRT1 来延缓神经退行性变的发生的饮食方案。
J Neurosci. 2013 May 22;33(21):8951-60. doi: 10.1523/JNEUROSCI.5657-12.2013.
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Enhanced optineurin E50K-TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma.增强型 OPTN E50K-TBK1 相互作用导致蛋白不可溶性，并引发家族性原发性开角型青光眼。
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