Institute of Chemistry & BioMedical Sciences (ICBMS), Nanjing University, Nanjing 210093, P. R. China.
Chem Commun (Camb). 2014 Feb 7;50(10):1259-61. doi: 10.1039/c3cc48509a.
The solution phase synthesis of N-protected amino acids and peptides has been achieved through the Group-Assisted Purification (GAP) chemistry by avoiding disadvantages of other methods in regard to the difficult scale-up, expenses of solid and soluble polymers, etc. The GAP synthesis can reduce the use of solvents, silica gels, energy and manpower. In addition, the GAP auxiliary can be conveniently recovered for re-use and is environmentally friendly and benign, and substantially reduces waste production in academic labs and industry.
通过 Group-Assisted Purification（GAP）化学，实现了 N-保护氨基酸和肽的溶液相合成，避免了其他方法在难以放大规模、固体和可溶性聚合物成本等方面的缺点。GAP 合成可以减少溶剂、硅胶、能源和人力的使用。此外，GAP 助剂可以方便地回收再利用，对环境友好且良性，可大大减少学术实验室和工业中的废物产生。
