Killgore William D S, Olson Elizabeth A, Weber Mareen
Social, Cognitive and Affective Neuroscience Lab, McLean Hospital, Harvard Medical School.
Sci Rep. 2013 Dec 12;3:3457. doi: 10.1038/srep03457.
Physical activity facilitates neurogenesis of dentate cells in the rodent hippocampus, a brain region critical for memory formation and spatial representation. Recent findings in humans also suggest that aerobic exercise can lead to increased hippocampal volume and enhanced cognitive functioning in children and elderly adults. However, the association between physical activity and hippocampal volume during the period from early adulthood through middle age has not been effectively explored. Here, we correlated the number of minutes of self-reported exercise per week with gray matter volume of the hippocampus using voxel-based morphometry (VBM) in 61 healthy adults ranging from 18 to 45 years of age. After controlling for age, gender, and total brain volume, total minutes of weekly exercise correlated significantly with volume of the right hippocampus. Findings highlight the relationship between regular physical exercise and brain structure during early to middle adulthood.
身体活动促进啮齿动物海马体齿状细胞的神经发生，海马体是大脑中对记忆形成和空间表征至关重要的区域。近期在人类中的研究结果还表明，有氧运动可导致儿童和老年人海马体体积增加以及认知功能增强。然而，从成年早期到中年这一时期，身体活动与海马体体积之间的关联尚未得到有效探究。在此，我们使用基于体素的形态计量学（VBM），对61名年龄在18至45岁之间的健康成年人进行研究，将他们每周自我报告的运动分钟数与海马体灰质体积进行关联分析。在控制了年龄、性别和全脑体积后，每周运动的总分钟数与右侧海马体体积显著相关。研究结果凸显了成年早期到中年期间规律体育锻炼与脑结构之间的关系。
