Liu Haiming, Graber Ted G, Ferguson-Stegall Lisa, Thompson LaDora V
Department of Physical Medicine and Rehabilitation, Program in Physical Therapy, University of Minnesota Medical School, Minneapolis.
J Gerontol A Biol Sci Med Sci. 2014 Dec;69(12):1485-91. doi: 10.1093/gerona/glt188. Epub 2013 Dec 13.
Frailty is a clinical syndrome associated with the aging process and adverse outcomes. The purpose of this short report was to initiate the development of a Frailty Index in 27- to 28-month-old C57BL/6 mice that matched the clinical criteria used in humans (weakness, slow walking speed, low activity level, poor endurance). The selected criteria included grip strength, walking speed, physical activity, and endurance. The criteria in mice were evaluated by the inverted-cling grip test, rotarod test, voluntary wheel running, and derived endurance scores. Each criterion had a designated cutoff point (1.5 SD below the cohort mean) to identify the mice with the lowest performance. If a mouse presented with three of the criteria scores below the cutoff points, it was identified as frail. Mild frailty was designated if two criteria were below the cutoff points. In this mouse cohort, one mouse was identified as frail and one was mildly frail. This prevalence of 9% frailty is consistent with the prevalence of frailty in humans at the same survival age. Collectively, our selected criterion, cutoff point, and Frailty Index provide a potential standardized definition for frailty in mice that is consistent with the operational definition of frailty in humans.
衰弱是一种与衰老过程及不良后果相关的临床综合征。本简短报告的目的是在27至28月龄的C57BL/6小鼠中开展衰弱指数的制定工作，该指数要符合人类使用的临床标准（虚弱、行走速度慢、活动水平低、耐力差）。选定的标准包括握力、行走速度、身体活动和耐力。通过倒悬握力测试、转棒试验、自主转轮运动和推算的耐力得分对小鼠的这些标准进行评估。每个标准都有一个指定的临界点（低于队列平均值1.5个标准差），以识别表现最差的小鼠。如果一只小鼠有三项标准得分低于临界点，则被认定为衰弱。如果有两项标准低于临界点，则被认定为轻度衰弱。在这个小鼠队列中，有一只小鼠被认定为衰弱，一只为轻度衰弱。这种9%的衰弱患病率与相同生存年龄的人类衰弱患病率一致。总体而言，我们选定的标准、临界点和衰弱指数为小鼠衰弱提供了一个潜在的标准化定义，该定义与人类衰弱的操作定义一致。
