Department of Neuroscience and Cell Biology, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
Learn Mem. 2013 Dec 16;21(1):1-4. doi: 10.1101/lm.032193.113.
The 5-HT3 receptor, the only ionotropic 5-HT receptor, is expressed in limbic regions, including the hippocampus, amygdala, and cortex. However, it is not known whether it has a role in fear memory processes. Analysis of 5-HT3A receptor knockout mice in fear conditioning paradigms revealed that the 5-HT3A receptor is not required for the acquisition or retention of fear memory but is essential for the extinction of contextual and tone-cued fear. Our data suggest that the 5-HT3A receptor could be a key molecule regulating fear memory processes and a potential therapeutic target for fear disorders.
5-HT3 受体是唯一的离子型 5-HT 受体，表达于边缘区域，包括海马、杏仁核和皮质。然而，其在恐惧记忆过程中是否具有作用尚不清楚。在恐惧条件反射范式中分析 5-HT3A 受体基因敲除小鼠表明，5-HT3A 受体对于恐惧记忆的获得或保持并非必需，但对于情境和音调线索恐惧的消退却是必需的。我们的数据表明，5-HT3A 受体可能是调节恐惧记忆过程的关键分子，也是恐惧障碍的潜在治疗靶点。
