School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China; Tasly R&D Institute, Tianjin Tasly Group Co., Ltd., Tianjin 300410, China.
Tasly R&D Institute, Tianjin Tasly Group Co., Ltd., Tianjin 300410, China.
Chin J Nat Med. 2013 Nov;11(6):577-87. doi: 10.1016/S1875-5364(13)60067-9.
The roots of Angelica sinensis (RAS), are a Chinese herbal medicine traditionally used in prescriptions for replenishing blood, treating abnormal menstruation, and other women's diseases. It has also been widely marketed as health food for women's care in Asia, and as a dietary supplement in Europe and America. RAS is well-known for its hematopoietic, antioxidant, and immunoregulatory activities. RAS also possesses anti-cancer, memory, radioprotective, and neuroprotective effects. Phytochemical investigations on this plant led to organic acids, phthalides, polysaccharides, and other metabolites. Based on recent animal studies and clinical trials, RAS has been used in the treatment of gynecologic diseases, cardio-cerebrovascular disease, nervous system diseases, and nephrotic syndrome. In this review, the recent phytochemical and pharmacological studies, drug-drug interactions, clinical applications, and toxicity of RAS are summarized.
当归的根是一种中药，传统上用于补血、治疗月经不调等妇科疾病的处方中。它也被广泛作为亚洲女性保健的保健品，并作为欧洲和美国的膳食补充剂销售。当归以其造血、抗氧化和免疫调节活性而闻名。当归还具有抗癌、记忆、放射保护和神经保护作用。对这种植物的植物化学研究导致了有机酸、苯酞、多糖和其他代谢物的产生。基于最近的动物研究和临床试验，当归已用于治疗妇科疾病、心脑血管疾病、神经系统疾病和肾病综合征。在这篇综述中，总结了当归的近期植物化学和药理学研究、药物相互作用、临床应用和毒性。
