The University of Arizona Cancer Center, Tucson, Arizona, USA.
Obesity (Silver Spring). 2014 May;22(5):E55-61. doi: 10.1002/oby.20683. Epub 2014 Jan 9.
Short sleep duration induces hormonal perturbations contributing to hyperphagia, insulin resistance, and obesity. The majority of these studies are conducted in young adults. This analysis in a large (n = 769) sample of postmenopausal women (median age 63 years) sought to (a) confirm that sleep duration and sleep quality are negatively correlated with circulating leptin concentrations and (b) to examine the relationship between self-reported sleep, dietary energy intake, and diet quality, as well as, investigate the role of leptin in these associations.
Sleep duration/quality, insomnia, and dietary intake were determined via self-report. Blood samples were collected following an overnight fast to assess serum leptin concentration. All analyses were adjusted for total body fat mass.
Women reporting ≤6 hr sleep/night had lower serum leptin concentrations than those reporting ≥8 hr sleep (P = 0.04). Furthermore, those with ≤6 hr sleep/night reported higher dietary energy intake (P = 0.01) and lower diet quality (P = 0.04) than the reference group (7 hr sleep/night). Women sleeping ≥8 hr also reported lower diet quality than the reference group (P = 0.02). Importantly, serum leptin did not confound these associations.
These results provide evidence that sleep duration is inversely associated with serum leptin and dietary energy intake in postmenopausal women.
睡眠时长过短会导致激素紊乱，进而引起多食、胰岛素抵抗和肥胖。这些研究大多针对年轻人进行。本分析针对绝经后女性（中位年龄 63 岁）这一大样本（n=769），旨在（a）证实睡眠时长和睡眠质量与循环瘦素浓度呈负相关；（b）研究自我报告的睡眠、膳食能量摄入和饮食质量之间的关系，并探究瘦素在这些关联中的作用。
通过自我报告确定睡眠时长/质量、失眠和膳食摄入量。采集过夜禁食后的血液样本以评估血清瘦素浓度。所有分析均调整了总体体脂量。
每晚睡眠时长≤6 小时的女性血清瘦素浓度低于每晚睡眠时长≥8 小时的女性（P=0.04）。此外，每晚睡眠时长≤6 小时的女性报告的膳食能量摄入更高（P=0.01），饮食质量更低（P=0.04），而 7 小时睡眠时长的女性为参照组。每晚睡眠时长≥8 小时的女性报告的饮食质量也低于参照组（P=0.02）。重要的是，血清瘦素并未混淆这些关联。
这些结果提供了证据，表明绝经后女性的睡眠时长与血清瘦素和膳食能量摄入呈负相关。
